Spatially resolved diffuse reflectance spectroscopy of two-layer turbid media by densely packed multi-pixel photodiode reflectance probe

Senlik, Ozlem; Greening, Gage J.; Muldoon, Timothy J.; Jokerst, N.M.

doi:10.1117/12.2213124

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The utility of SRDRS for quantitative optical characterization of tissues has been widely recognized [18][19][20][21][22]. The increased dimensionality of the DRS data yields increased information density for the unique determination of tissue optical properties, and the illumination/detection separations of SRDRS probes may be optimized for specific tissue applications to reduce noise and target specific interrogation depths [23,24].…”

Section: Introductionmentioning

confidence: 99%

Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors

LaRiviere

Garman

Ferguson

et al. 2018

Biomed. Opt. Express

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Early detection and surveillance of disease progression in epithelial tissue is key to improving long term patient outcomes for colon and esophageal cancers, which account for nearly a quarter of cancer related mortalities worldwide. Spatially resolved diffuse reflectance spectroscopy (SRDRS) is a non-invasive optical technique to sense biological changes at the cellular and sub-cellular level that occur when normal tissue becomes diseased, and has the potential to significantly improve the current standard of care for endoscopic gastrointestinal (GI) screening. Herein the design, fabrication, and characterization of the first custom SRDRS device to enable endoscopic SRDRS GI tissue characterization using a custom silicon (Si) thin film multi-pixel endoscopic optical sensor (MEOS) is described. Depeursinge, "In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties," J. Biomed. Opt. 8(3), 495-503 (2003). 11. Z. Ge, K. T. Schomacker, and N. S. Nishioka, "Identification of colonic dysplasia and neoplasia by diffuse reflectance spectroscopy and pattern recognition techniques," Appl. Spectrosc. 52(6), 833-839 (1998 Marcu, "Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm," Appl. Opt. 43(14), 2846-2860 (2004) Opt. Express 8(3), 1512-1524 (2017 Wilke, and N. Ramanujam, "Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins," Opt.

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Section: Introductionmentioning

confidence: 99%

Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors

LaRiviere

Garman

Ferguson

et al. 2018

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

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Flexible silicon sensors for diffuse reflectance spectroscopy of tissue

Miller¹,

Jokerst²

2017

Biomed. Opt. Express

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Diffuse reflectance spectroscopy (DRS) is being used in exploratory clinical applications such as cancer margin assessment on excised tissue. However, when interrogating nonplanar tissue anomalies can arise from non-uniform pressure. Herein is reported the design, fabrication, and test of flexible, thin film silicon photodetectors (PDs) bonded to a flexible substrate designed for use in conformal DRS. The PDs have dark currents and responsivities comparable to conventional Si PDs, and were characterized while flat and while flexed at multiple radii of curvature using liquid phantoms mimicking adipose and malignant breast tissue. The DRS and nearest neighbor crosstalk results were compared with Monte Carlo simulations, showing good agreement between simulation and experiment. . 11. G. Zonios, J. Bykowski, and N. Kollias, "Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy," J. Invest. Dermatol. 117(6), 1452-1457 (2001). 12. A. Garcia-Uribe, J. Zou, M. Duvic, J. H. Cho-Vega, V. G. Prieto, and L. V. Wang, "In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry," Cancer Res. 72(11), 2738-2745 (2012). 13. N. Subhash, J. R. Mallia, S. S. Thomas, A. Mathews, P. Sebastian, and J. Madhavan, "Oral cancer detection using diffuse reflectance spectral ratio R540/R575 of oxygenated hemoglobin bands," J. Biomed. Opt. 11(1), 014018 and N. Ramanujam, "Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins," Opt.

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Spatially resolved diffuse reflectance spectroscopy of two-layer turbid media by densely packed multi-pixel photodiode reflectance probe

Cited by 2 publications

References 7 publications

Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors

Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors

Flexible silicon sensors for diffuse reflectance spectroscopy of tissue

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