Spatially Resolved Diffuse Reflectance Spectroscopy of Tumor and Normal Excised Human Colon with Thin Film Si Sensors

LaRiviere, Ben; Garman, Katherine S.; Ferguson, N. Lynn; Fisher, Deborah A.; Jokerst, N.M.

doi:10.1364/sensors.2019.stu2d.5

Cited by 1 publication

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“…Indeed, photons detected at a short/large source-detector (SD) distance will be associated with shallower/deeper trajectories into the biological tissues under evaluation. The literature on this subject points to numerous applications of SR-DRS such as the measurement of blood glucose levels [5,6], hemoglobin oxygen saturation [7] and for pre-cancer and cancer diagnosis: lung [8], cervix [9], colon [10], bladder [11], brain [12], breast [13], oesophagus [14] or pancreas [15]. There are also a large number of applications of SR-DRS for the in vivo characterization of cutaneous pathological states, including melanoma [16][17][18] and carcinoma [19,20], and more generally for the characterization of skin layer optical properties [21,22].…”

Section: Introductionmentioning

confidence: 99%

Proposal for a Skin Layer-Wise Decomposition Model of Spatially-Resolved Diffuse Reflectance Spectra Based on Maximum Depth Photon Distributions: A Numerical Study

et al. 2021

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In the context of cutaneous carcinoma diagnosis based on in vivo optical biopsy, Diffuse Reflectance (DR) spectra, acquired using a Spatially Resolved (SR) sensor configuration, can be analyzed to distinguish healthy from pathological tissues. The present contribution aims at studying the depth distribution of SR-DR-detected photons in skin from the perspective of analyzing how these photons contribute to acquired spectra carrying local physiological and morphological information. Simulations based on modified Cuda Monte Carlo Modeling of Light transport were performed on a five-layer human skin optical model with epidermal thickness, phototype and dermal blood content as variable parameters using (i) wavelength-resolved scattering and absorption properties and (ii) the geometrical configuration of a multi-optical fiber probe implemented on an SR-DR spectroscopic device currently used in clinics. Through histograms of the maximum probed depth and their exploitation, we provide numerical evidence linking the characteristic penetration depth of the detected photons to their wavelengths and four source–sensor distances, which made it possible to propose a decomposition of the DR signals related to skin layer contributions.

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