Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens

Reiß, Stephan; Burau, Gerolf; Stachs, Oliver; Guthoff, Rudolf; Stolz, H.

doi:10.1364/boe.2.002144

Cited by 61 publications

(50 citation statements)

References 32 publications

(56 reference statements)

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“…[5][6][7][8] Brillouin scattering originates from the inelastic interaction between the incident electromagnetic wave and the acoustic phonons within the material. As a result, the incident optical frequency experiences a shift proportional to the speed of sound in the medium.…”

Section: Introductionmentioning

confidence: 99%

Optimizing signal collection efficiency of the VIPA-based Brillouin spectrometer

Meng

Yakovlev

2015

J. Innov. Opt. Health Sci.

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Brillouin spectroscopy is an emerging tool for microscopic optical imaging as it allows for noninvasive and direct assessment of the viscoelastic properties of materials. Recent advances of background-free confocal Brillouin spectrometer allows investigators to acquire the Brillouin spectra for turbid samples as well as transparent ones. However, due to strong signal loss induced by the imperfect optical setup, the Brillouin photons are usually immersed in background noise. In this report, we proposed and experimentally demonstrated multiple approaches to enhance the signal collection e±ciency. A signal enhancement by > 4 times can be observed, enabling observation of ultra-weak signals.

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Section: Introductionmentioning

confidence: 99%

Optimizing signal collection efficiency of the VIPA-based Brillouin spectrometer

Meng

Yakovlev

2015

J. Innov. Opt. Health Sci.

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“…It provides unique information on the samples' viscoelastic properties [1] and is widely used in remote sensing [3,4], material science [5,6] and, more recently, biomedical applications [7][8][9][10][11]. Brillouin scattering originates from the inelastic interaction between the incident electromagnetic wave and acoustic phonons in a material.…”

Section: Introductionmentioning

confidence: 99%

Surface-enhanced Brillouin scattering in a vicinity of plasmonic gold nanostructures

2015

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Brillouin spectroscopy is a powerful tool for non-invasive elasticity-specific optical imaging. We report an observation of enhancements of Brillouin scattering from liquid samples in the presence of gold nanostructures. These enhancements are attributed to surface plasmons generated by nanostructures and are found to be dependent on the nanostructures' architecture (i.e. their sizes and aspect ratios). These observations suggest that plasmonic nanostructures composed of nanodisk arrays can provide a platform for practical implementation of surfaceenhanced Brillouin scattering, which is capable of localizing interaction to a nanoscopic volume to facilitate high spatial resolution elasticity measurements. KEYWORDSSpontaneous Brillouin scattering, Brillouin spectroscopy, surface enhanced Brillouin scattering, virtually imaged phased array (VIPA)

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“…Besides acoustic imaging techniques, Brillouin optical microscopy has recently been used to evaluate the elastic properties of the crystalline lens [11,12]. This method applies Brillouin spectroscopy to measure the frequency shift of the scattered light from the interaction between photons and acoustic phonons.…”

Section: Introductionmentioning

confidence: 99%

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Wang

Aglyamov

Karpiouk

et al. 2013

Biomed. Opt. Express

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Abstract:We demonstrate the feasibility of using the dominant frequency of the sample surface response to a mechanical stimulation as an effective indicator for sensing the depthwise distribution of elastic properties in transparent layered phantom samples simulating the cortex and nucleus of the crystalline lens. Focused ultrasound waves are used to noninvasively interrogate the sample surface. A phase-sensitive optical coherence tomography system is utilized to capture the surface dynamics over time with nanometer scale sensitivity. Spectral analysis is performed on the sample surface response to ultrasound stimulation and the dominant frequency is calculated under particular loading parameters. Pilot experiments were conducted on homogeneous and layered tissuemimicking phantoms. Results indicate that the mechanical layers located at different depths introduce different frequencies to the sample surface response, which are correlated with the depth-dependent elasticity of the sample. The duration and the frequency of the ultrasound excitation are also investigated for their influences on this spectrum-based detection. This noninvasive method may be potentially applied for localized and rapid assessment of the depth dependence of the mechanical properties of the crystalline lens.

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Spatially resolved Brillouin spectroscopy to determine the rheological properties of the eye lens

Cited by 61 publications

References 32 publications

Optimizing signal collection efficiency of the VIPA-based Brillouin spectrometer

Optimizing signal collection efficiency of the VIPA-based Brillouin spectrometer

Surface-enhanced Brillouin scattering in a vicinity of plasmonic gold nanostructures

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

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