Spatially resolved birefringence of the retinal nerve fiber layer assessed with a retinal laser ellipsometer

Dreher, Andreas W.; Reiter, Klaus; Weinreb, Robert N.

doi:10.1364/ao.31.003730

Cited by 201 publications

(139 citation statements)

References 16 publications

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“…The amount of phase shift is called retardation and is correlated linearly with the thickness of the RNFL. 4,5 In this study, we have evaluated the effects of DM, degree of metabolic control of DM and the presence of DR on RNFL thickness by using NFAGDx.…”

Section: Diabetic Retinopathy (Dr) Is the Most Common Ocular Complicamentioning

confidence: 99%

Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry

Özdek

Önol

et al. 2002

Eye

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Objective To evaluate the effects of diabetes mellitus, diabetic retinopathy and degree of blood glucose (BG) regulation on retinal nerve fiber layer (RNFL) thickness by using a scanning laser polarimeter (NFAGDx). Methods We prospectively assessed RNFL thickness in four groups of patients, who were all age matched. Diabetic patients without diabetic retinopathy were grouped according to their BG regulation level into two, as: BG-regulated group (BG Ͻ140 mg/dl, HbA1c Ͻ8%, fructosamine Ͻ285 mol/l, TG Ͻ200 mg/dl, n = 50), and BG-non-regulated group (BG = 140-250 mg/dl, HbA1c Ͼ8%, fructosamine Ͼ285 mol/l, TG Ͼ200 mg/dl, n = 44). A group of patients with nonproliferative diabetic retinopathy (NPDR) formed the 3rd group (n = 41). The 4th group consisted of healthy subjects and acted as a control group (n = 50). Symmetry, superior maximum, ellipse modulation and the average thickness variables of NFA-GDx were used for the assessment. ANOVA test was used for the statistical analysis of variables between groups. Results The mean superior maximum and ellipse modulation values were statistically significantly lower than the control group in BG-non-regulated and NPDR groups (P Ͻ 0.05). The average thickness value was also statistically significantly lower than the control group in NPDR group. These values in the BG-regulated group were not statistically significantly different from the control group (P Ͼ 0.05). Conclusions This is the first clinical study demonstrating the effects of diabetic glucose regulation level on RNFL by using NFAGDx. RNFL thickness was seen to decrease with development of diabetic retinopathy and with impairment of metabolic regulation. This issue should be taken into account while assessing RNFL in diabetic glaucomatous patients.

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Section: Diabetic Retinopathy (Dr) Is the Most Common Ocular Complicamentioning

confidence: 99%

Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry

Özdek

Önol

et al. 2002

Eye

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“…4,5 Scanning laser polarimetry (SLP) has successfully been used to measure thickness of the nerve fibre layer outside the fovea. [6][7][8] Also, polarimetry images of the fovea show a characteristic 'bowtie' pattern. [9][10][11][12][13][14][15][16][17][18][19][20] This pattern is thought to result from an interaction of corneal and foveal birefringence.…”

Section: Introductionmentioning

confidence: 99%

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Weber

Elsner

Miura

et al. 2006

Eye

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Purpose To investigate the relationship between visual acuity and foveal birefringence in patients with neovascular age-related macular degeneration. Methods In total, 40 patients with choroidal neovascularization underwent macular imaging with scanning laser polarimetry. Bowtie patterns, typically seen in birefringence images of the macula, were evaluated and classified into three categories: (1) regular bowtie present; (2) bowtie present, but disrupted; and (3) no bowtie present. The relation of the bowtie appearance to the best-corrected logMAR visual acuities was tested (ANOVA). Results Mean visual acuity was best for the group that had regular bowties (mean logMAR ¼ 0.34) and differed statistically significantly from the disrupted bowtie group and no bowtie group (P ¼ 0.01 and 0.0007). Ages for the three groups did not differ (P ¼ 0.31). Conclusions Appearance of a regular bowtie indicates a substantially intact Henle fibre layer with the potential for good visual function, despite the presence of underlying pathology. Conversely, disruption or absence of a bowtie may indicate severe damage to the photoreceptors, consistent with the finding of poorer visual acuity.

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“…The appearance of alterations in the retinal nerve fibre layer (RNFL) represents an early sign of glaucoma damage that precedes the optic nerve changes and peripheral alterations. 1,2 The quantitative investigation techniques proposed for the study of the RNFL are scanning laser polarimetry (SLP), 3,4 Heidelberg retinal tomography (HRT), 5,6 and more recently optical coherence tomography (OCT). OCT is a technique that makes it possible to examine high-resolution cross-sections of ocular tissues using the low coherence interferometry principle [7][8][9][10] and it seems more reliable than SLP and HRT in the study of RNFL.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Spatially resolved birefringence of the retinal nerve fiber layer assessed with a retinal laser ellipsometer

Cited by 201 publications

References 16 publications

Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry

Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

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