Spatially non-overlapping Ca2+ signals drive distinct forms of neurotransmission

Wang, Camille S.; Monteggia, Lisa M.; Kavalali, Ege T.

doi:10.1016/j.celrep.2023.113201

Cited by 5 publications

(1 citation statement)

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“…NMDA receptors are also expressed at presynaptic terminals, and Ca 2+ influx through NMDA receptors contributes to synaptic function. However, increases in Ca 2+ concentration at presynaptic terminals for transmitter release are predominantly caused by the opening of voltage-gated Ca 2+ channels [ 61 , 62 ]. Indeed, functional Ca 2+ stores exist in synaptic terminals and the stored Ca 2+ can be released either spontaneously or by Ca 2+ influx through VGCCs.…”

Section: Discussionmentioning

confidence: 99%

Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor

Kanayama,

Tominaga,

Tominaga

et al. 2024

J Physiol Sci

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The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8–10 Hz was elicited in rat brain slices after caffeine application. Oscillations comprised a non-NMDA receptor-dependent initial phase and a later NMDA receptor-dependent oscillatory phase, with the oscillator located in the upper layer of the OSC. Baclofen was applied to investigate the actions of GABAB receptors. The later NMDA receptor-dependent oscillatory phase completely disappeared, but the initial phase did not. These results suggest that GABAB receptors mainly act on NMDA receptor, in which metabotropic actions of GABAB receptors may contribute to the attenuation of NMDA receptor activities. A regulatory system for network oscillation involving GABAB receptors may be present in the OSC.

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Section: Discussionmentioning

confidence: 99%