We demonstrate genuine multipartite quantum entanglement of four photons in their orbital angular momentum degrees of freedom, where a high-dimensional discrete Hilbert space is attached to each photon. This can encode more quantum information compared to the qubit case, but it is a long-standing problem to entangle more than two such photons. In our experiment we use pulsed spontaneous parametric down-conversion to produce the photon quadruplets, which allows us to detect about one four-photon event per second. By means of quantum state reconstruction and a suitable witness operator we find that the photon quadruplets form a genuine multipartite entangled symmetric Dicke state. This opens a new tool for addressing foundational questions in quantum mechanics, and for exploration of novel high-dimensional multiparty quantum information applications such as secret sharing. DOI: 10.1103/PhysRevLett.116.073601 Experimental control over systems where more than two particles are entangled is of interest for the study of foundational questions in quantum mechanics, and for multiparty quantum information schemes. So far, up to 14 particles have been entangled [1,2], but in each case the single-particle Hilbert space was strictly two-dimensional, i.e., qubits. For photons, the spatial degrees of freedom enable high-dimensional single particle spaces, which can be discretized in the photon orbital angular momentum (OAM). This enables implementation of novel quantum information protocols [3][4][5], and the study of fundamentally new quantum states [6,7]. To date, only two such multidimensional particles have been entangled [8,9] albeit with ever increasing dimensionality [10][11][12]; only in continuous variables, a first study goes beyond this [13]. Here, we use pulsed spontaneous parametric downconversion (SPDC) [14] to produce photon quadruplets that are entangled in their OAM, or transverse-mode, degrees of freedom [8,15], and witness genuine multipartite Dicke-type entanglement [16][17][18]. Apart from addressing foundational questions [19][20][21], this could find applications in quantum metrology, imaging, and secret sharing [22,23].Photons that are generated by near-collinear SPDC are correlated in several degrees of freedom and exhibit quantum entanglement. Apart from the well-known polarization degrees, the photons can also be correlated in their spatial degrees; this manifests itself in continuous wave vector or (the Fourier-related) position entanglement. This can be discretized using transverse optical modes, and a particular useful choice for experiments is the LaguerreGauss (LG) modes. Their azimuthal part factorizes and describes phase vortices [24] exp ðilϕÞ, where ϕ is the azimuth and l ¼ −∞, …, ∞ determines the twisting number of the wave front, corresponding to an orbital angular momentum of lℏ per photon [25] (in addition to the spin angular momentum). The LG and the related Hermite-Gauss modes have well-known propagation dynamics; thus, they are suitable for the long-distance distribution of high-d...