Spatial working memory span, delayed response and executive function in schizophrenia

Chey, Jeanyung; Lee, Jung‐Hee; Kim, Yong-Sik; Kwon, Suk-Man; Shin, Youngmin

doi:10.1016/s0165-1781(02)00105-1

Cited by 56 publications

(33 citation statements)

References 41 publications

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“…In accordance with our finding that the PICK1 genetic variation (rs2076369) in schizophrenic patients may associate with spatial working memory, review articles also show that schizophrenic patients have more severe dysfunction of spatial working memory compared to healthy controls 42 . Apart from, the results of knock-in mice lacking the PDZ-ligand motif of mGluR7a (metabotropic glutamate receptor 7a), with disruption of PICK1-mGluR7a interaction, also demonstrate spatial working memory deficits 43 .…”

Section: Discussionsupporting

confidence: 91%

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Chen

Lin

Huang

et al. 2017

Sci Rep

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The gene of protein interacting with C kinase 1 alpha (PICK1) has been implicated in schizophrenia, nevertheless, conflicting results existed. However, its role in cognitive function remains unclear. Besides, cognitive deficits impair the long-term outcome. We explored whether the polymorphisms of PICK1 (rs2076369, rs3952) affected cognitive functions in schizophrenic patients. We analyzed 302 patients and tested the differences of cognitive functions, clinical symptoms between genetic groups. We also used general linear model to analyze the effect of PICK1 genetic polymorphisms on cognitive functions. After adjustment for gender, age, education, the patients with rs2076369 G/T genotype showed better performance than T/T homozygotes in the summary score, global composite score, neurocognitive composite score, category fluency subtest, WAIS-III-Digit Symbol Coding subtest, working memory, WMS-III-Spatial Span (backward) subtest, MSCEIT-managing emotions branch (p = 0.038, 0.025, 0.046, 0.036, 0.025, 0.027, 0.035, 0.028, respectively). G/G homozygotes performed better than T/T in category fluency subtest (p = 0.049). A/A homozygotes of rs3952 performed better than G/G in trail making A subtest (p = 0.048). To our knowledge, this is the first study to indicate that PICK1 polymorphisms may associate with cognitive functions in schizophrenic patients. Further replication studies in healthy controls or other ethnic groups are warranted.

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Section: Discussionsupporting

confidence: 91%

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

Chen

Lin

Huang

et al. 2017

Sci Rep

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“…It is extensively used in diagnostics for the assessment of visuo-spatial working memory (VSWM), but it also involves spatial attention (Smyth and Scholey, 1994). Moreover, it is often used as part of test batteries in the diagnostics of several diseases such as the early detection of Alzheimer's disease (Carlesimo et al, 1994), Korsakoff's syndrome (Haxby et al, 1983), schizophrenia (Chey et al, 2002), and to support hypotheses about the localization of focal brain lesions (Milner, 1971; De Renzi et al, 1977). …”

Section: Introductionmentioning

confidence: 99%

eCorsi: implementation and testing of the Corsi block-tapping task for digital tablets

2014

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The Corsi block-tapping task is a widely used test to assess visuo-spatial working memory. The test is traditionally administered using nine square blocks positioned on a wooden board, but numerous digital versions have been developed. In this study, we tested one-hundred and seven participants divided into two age groups (18–30 and over 50) in forward, backward and supraspan-forward conditions with eCorsi, a tablet version of the Corsi task. Compared to the traditional physical board, eCorsi has several advantages, including: simple installation, set-up, and use; considerably increased accuracy in presentation timing, automatic measures of span and reaction times, in both the forward and backward response modalities. Results showed that average span and error rates were essentially analogous to the ones obtained in the main standardization studies, which have used the original physical version of the Corsi test. Furthermore, timing results provide new indications about the mechanisms underlying spatial sequence processing, suggesting that the subject's response is not planned during sequence presentation, but between the end of the presentation and the beginning of the response.

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“…In animals, working memory has been assessed using a variety of different tasks, many of which relate solely to the short-term storage of information over delays, without assessment of the capacity of working memory (Dudchenko, 2004; Dudchenko et al, 2012). In schizophrenia, working memory capacity is decreased (Chey et al, 2002; Gold et al, 2010) and the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) group has identified capacity as a component of working memory requiring more basic research before being included in the translational battery (Barch and Smith, 2008; Dudchenko et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

GluN2B-containing NMDA receptors and AMPA receptors in medial prefrontal cortex are necessary for odor span in rats

Davies

Greba

Howland

2013

Front. Behav. Neurosci.

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Working memory is a type of short-term memory involved in the maintenance and manipulation of information essential for complex cognition. While memory span capacity has been extensively studied in humans as a measure of working memory, it has received considerably less attention in rodents. Our aim was to examine the role of the N-methyl-D-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors in odor span capacity using systemic injections or infusions of receptor antagonists into the medial prefrontal cortex (mPFC). Long Evans rats were trained on a well-characterized odor span task (OST). Initially, rats were trained to dig for a food reward in sand followed by training on a non-match to sample discrimination using sand scented with household spices. The rats were then required to perform a serial delayed non-match to sample procedure which was their odor span. Systemic injection of the broad spectrum NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) (10 mg/kg) or the GluN2B-selective antagonist Ro 25-6981 (10 mg/kg but not 6 mg/kg) significantly reduced odor span capacity. Infusions of the GluN2B- selective antagonist Ro 25-6981 (2.5 μg/hemisphere) into mPFC reduced span capacity, an effect that was nearly significant (p = 0.069). Infusions of the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (1.25 μg/hemisphere) into mPFC reduced span capacity and latency for the rats to make a choice in the task. These results demonstrate span capacity in rats depends on ionotropic glutamate receptor activation in the mPFC. Further understanding of the circuitry underlying span capacity may aid in the novel therapeutic drug development for persons with working memory impairments as a result of disorders such as schizophrenia and Alzheimer’s disease.

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Spatial working memory span, delayed response and executive function in schizophrenia

Cited by 56 publications

References 41 publications

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

PICK1 Genetic Variation and Cognitive Function in Patients with Schizophrenia

eCorsi: implementation and testing of the Corsi block-tapping task for digital tablets

GluN2B-containing NMDA receptors and AMPA receptors in medial prefrontal cortex are necessary for odor span in rats

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