Spatial versus verbal memory impairments in patients with fibromyalgia

Abstract

Mounting evidence suggests that individuals with fibromyalgia (FM) have impairments in general cognitive functions. However, few studies have explored the possibility of dissociation between verbal and visuospatial memory impairments in FM. Therefore, the purpose of this study was to investigate the asymmetrical impairment of cognitive functions between verbal and visuospatial memory and between short-term and long-term memory. Neuropsychological assessments were carried out on 23 female patients with FM and 24 healthy female controls. Verbal memory abilities were assessed using the Korean version of the Rey auditory verbal learning test (KAVLT) and digit span task, and visuospatial memory abilities were assessed using the Korean version of the Rey complex figure test (KCFT) and spatial span task. The analysis of covariance was used to assess group differences in performance on cognitive tests after controlling for depression. The two groups did not significantly differ in terms of age, years of education, or in their estimated verbal and performance IQ, but FM patients reported more severe depressive symptoms than did controls on the Beck depression inventory. Significant group differences were found in immediate and delayed recall on the KCFT (F (1,44) = 6.49, p = 0.014 and F (1,44) = 6.96, p = 0.011, respectively), whereas no difference was found in immediate and delayed recall on the KAVLT. In terms of short-term memory, neither the digit span task nor spatial span task showed any difference between groups, regardless of whether repetition was forward or backward. These findings suggest that spatial memory abilities may be more impaired than verbal memory abilities in patients with FM.

Fibromyalgia: A Critical and Comprehensive Review

“…Depression or depressive symptoms show associations with some of the cognitive dysfunction in FMS, but they fully explain them in only a few studies, partly explain them in others, and do not show any association in the remainder [187,191,192,198,200,206]. These discrepancies may arise because the effects of depressive symptoms appear to be domain-or even task-specific [183,198,209] and because different instruments were used for assessing depressive symptoms.…”

“…While addressed in fewer studies, certain measures of semantic memory also show impairments in FMS, including decreased verbal fluency, naming speed, and vocabulary [187,195,197]. However, recent data suggest that deficits may be more pronounced in visuospatial than in verbal memory [198,199]. Inconsistent results have been reported for episodic and implicit memory [187,195,200,201].…”

“…Patient with FMS consider fatigue to have a great impact on their cognitive function [212], and self-reported fatigue is associated with perceived dyscognition [174,179,213], but the majority of investigations do not reveal a major impact of fatigue on objective cognitive performance [187,191,192,198,206]. Daytime sleepiness correlated with a lower rate of correct responses during a mental arithmetic task in the patient group [203], but was not significantly associated with performance on a go/no-go task [191].…”

“…These discrepancies may arise because the effects of depressive symptoms appear to be domain-or even task-specific [183,198,209] and because different instruments were used for assessing depressive symptoms. Other methodological differences and patient heterogeneity are also likely to contribute to the observed inconsistencies.…”

Fibromiyaljide Kognitif Disfonksiyon

“…Buna rağmen işitsel (verbal) ve görsel-çevresel (visuo-spasyal) hafıza bozuklukları ile ilişkili bir kaç çalışma mevcuttur. Kim ve arkadaşlarının 27 yaptığı çalışmada FMS hastalarında görsel-çevresel hafızanın daha fazla bozulduğu gözlenmiştir.…”