“…Therefore, it is desirable to have linearly-independent sensitivity coefficients, J ij , with large magnitude so that the inverse problem is not very sensitive to measurements errors, and accurate estimations of the parameters can be obtained. The maximization of |F|, called D-optimality method reported by Alifanov et al (1995) and Garcia (1999), is generally aimed to design optimum experiments for the estimation of the unknown parameters, because the confidence region of the estimations is then minimized as Arunkumar et al (2008) reported. Generally, the time-wise variations of sensitivity coefficients and |F| must be examined before attempting to solve the inverse problem.…”