Spatial variation in nitrogen dioxide concentrations and cardiopulmonary hospital admissions

Dijkema, Marieke; Strien, R.T. van; Zee, Saskia C. van der; Mallant, Sanne F; Fischer, Paul; Hoek, Gerard; Brunekreef, Bert; Gehring, Ulrike

doi:10.1016/j.envres.2016.09.008

Cited by 21 publications

(11 citation statements)

References 38 publications

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“…50 In this study, a significant and direct relation was observed between short-term exposure to PM 2.5 , NO 2 , NO, CO, and hospital admissions due to COPD in the total population, women, men, adults, and the elderly. Other studies have shown the significant effect of increased ambient NO 2 with hospital admissions due to COPD or asthma in Shiraz, Iran; 51 the Netherlands, 20 and Italy. 52 In Taiwan, increase in PM 2.5 and PM 10 , increased hospital admissions for COPD, asthma, and pneumonia; 19,53 and in Italy increase in PM 10 , increased the risk of hospitalization due to COPD in the whole year, and this effect was stronger in the warm season.…”

Section: Discussionmentioning

confidence: 94%

“…[5][6][7] The effects of air pollution on the respiratory system include increased respiratory symptoms, decreased lung function, and increased incidence of chronic cough and bronchitis. 8,9 Epidemiological and clinical studies show that in children and adults, increased hospital admissions, lung diseases, lung cancer, 10 bronchiectasis, [11][12][13][14] respiratory infection, pulmonary embolism, asthma, 2,6,[15][16][17][18] and chronic obstructive pulmonary diseases (COPD) 9,[19][20][21][22][23] are affected by air pollution.…”

Section: Introductionmentioning

confidence: 99%

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<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Raji¹,

Riahi²,

Borsi³

et al. 2020

COPD

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Background and Aim: Although air pollution is a serious problem in Ahvaz, the association between air pollution and respiratory diseases has not been studied enough in this area. The aim of this study was to determine the relation between short-term exposure to air pollutants and the risk of hospital admissions due to asthma, COPD, and bronchiectasis in Ahvaz. Methods: Hospital admissions data and air pollutants including O 3 , NO, NO 2 , SO 2 , CO, PM 10, and PM 2.5 were obtained from 2008 to 2018. Adjusted Quasi-Poisson regression with a distributed lag model, controlled for trend, seasonality, weather, weekdays, and holidays was used for data analysis. Results: The results showed a significant increase in hospital admissions for asthma (RR=1.004, 95% CI: 1.002-1.007) and COPD (RR=1.003, 95% CI: 1.001-1.005) associated with PM 2.5 . PM 10 was associated with increased hospital admissions due to bronchiectasis in both genders (Men: RR=1.003, 95% CI: 1.001-1.006) (Female: RR=1.003, 95% CI: 1.000-1.006). NO 2 was also associated with an increased risk of hospital admissions for asthma (RR=1.040, 95% CI: 1.008-1.074) and COPD (RR=1.049, 95% CI: 1.010-1.090). SO 2 was associated with the risk of hospital admissions of asthma (RR=1.069, 95% CI: 1.017-1.124) and bronchiectasis (RR=1.030, 95% CI: 1.005-1.056). Finally, CO was associated with COPD (RR=1.643, 95% CI: 1.233-2.191) and bronchiectasis (RR=1.542, 95% CI: 1.035-2.298) hospital admissions. Conclusion: Short-term exposure to air pollutants significantly increases the risk of hospital admissions for asthma, COPD, and bronchiectasis in the adult and elderly population.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Raji¹,

Riahi²,

Borsi³

et al. 2020

COPD

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“…The geographical heterogeneity can be accounted for (at least in part) by disparities in socio-economic factors (such income and educational level, which are associated with inequality in health access) and in health-related behaviours (such as dietary habits, physical activity, and smoking). By using spatial ecological analyses adjusted for the socio-economic level, several research groups have reported associations between air pollution and CHD (Barceló et al, 2009;Bennett et al, 2014;Chen et al, 2015;Dijkema et al, 2016;Garcia et al, 2016;Hu and Rao, 2009;Maheswaran et al, 2005;Pannullo et al, 2016;Pascal et al, 2013) using mortality or hospitalization rates indicators. Much less is known on the effect of environmental factors on CHD incidence rates.…”

Section: Introductionmentioning

confidence: 99%

Exposure to multiple air pollutants and the incidence of coronary heart disease: A fine-scale geographic analysis

Occelli

Lanier

Cuny

et al. 2020

Science of The Total Environment

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Geographical variations in cardiovascular disease rates have been linked to individual air pollutants. Investigating the relation between cardiovascular disease and exposure to a complex mixture of air pollutants requires holistic approaches. We assessed the relationship between exposure to multiple air pollutants and the incidence of coronary heart disease (CHD) in a general population sample. We collected data in the Lille MONICA registry (2008-2011) on 3268 incident cases (age range: 35-74). Based on 20 indicators, we derived a composite environmental score (SEnv) for cumulative exposure to air pollution. Poisson regression models were used to analyse associations between CHD rates on one hand and SEnv and each single indicator on the other (considered in tertiles, where T3 is the most contaminated). We adjusted models for age, sex, area-level social deprivation, and neighbourhood spatial structure. The incidence of CHD was a spatially heterogeneous (p=0.006). There was a significant positive association between SEnv and CHD incidence (trend p=0.0151). The relative risks [95%CI] of CHD were 1.08 [0.98-1.18] and 1.16 [1.04-1.29] for the 2nd and 3rd tertile of SEnv exposure. In the single pollutant analysis, PM 10 , NO 2 , cadmium, copper, nickel, and palladium were significantly associated with CHD rates. Multiple air pollution was associated with an increased risk of CHD. Single pollutants reflecting road traffic pollution were the most strongly associated with CHD. Our present results are consistent with the literature data on the impact of road traffic on the CHD risk in urban areas.

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“…In particular, epidemiological studies found a linear and positive association between short-term exposure to NO 2 and total, cardiovascular, and respiratory mortality in several Chinese cities (Chen et al 2012. Positive associations of outdoor NO 2 levels with hospital admissions of all cardiovascular causes, ischemic heart disease and stroke, and respiratory diseases were also found in American older adults (Eum et al 2019) and in Netherlands residents (Dijkema et al 2016). Taken together, NO 2 in fresh DE might contribute to more adverse cardiac effects in the current study.…”

Section: Discussionmentioning

confidence: 93%

Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice

Tong

Zavala

McIntosh-Kastrinsky

et al. 2019

Journal of Toxicology and Environmental Health, Part A

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This study was designed to compare the cardiovascular effects of inhaled photochemically-altered diesel exhaust (aged DE) to freshly-emitted DE (fresh DE) in female C57Bl/6 mice. Mice were exposed to either fresh DE, aged DE, or filtered air (FA) for 4 hr using an environmental irradiation chamber. Cardiac responses were assessed 8 hr after exposure utilizing Langendorff preparation with a protocol consisting of 20 min of perfusion and 20 min of ischemia followed by 2 hr of reperfusion. Cardiac function was measured by indices of left-ventricular developed pressure (LVDP) and contractility (dP/dt) prior to ischemia. Recovery of post-ischemic LVDP was examined on reperfusion following ischemia. Fresh DE contained 460 μg/m 3 of particulate matter (PM), 0.29 ppm of nitrogen dioxide (NO 2) and no ozone (O 3), while aged DE consisted of 330 μg/m 3 of PM, 0.23 ppm O 3 and no NO 2. Fresh DE significantly decreased LVDP, dP/dt max , and dP/dt min compared to FA. Aged DE also significantly reduced LVDP and dP/dt max. Data demonstrated that acute inhalation to either fresh or aged DE lowered LVDP and dP/dt, with a greater fall noted with fresh DE, suggesting that the composition of DE may play a key role in DEinduced adverse cardiovascular effects in female C57Bl/6 mice.

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Spatial variation in nitrogen dioxide concentrations and cardiopulmonary hospital admissions

Cited by 21 publications

References 38 publications

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Exposure to multiple air pollutants and the incidence of coronary heart disease: A fine-scale geographic analysis

Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice

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