Mixed siliciclastic-carbonate deep-marine systems, herein termed ‘mixed systems’, are less well documented than their siliciclastic-dominated counterparts, but may be common globally and misinterpreted as transient transition zones between carbonate and siliciclastic deposition. The well-exposed Upper Cretaceous mixed-system of the Buduq Trough, Eastern Greater Caucasus (EGC), Azerbaijan, provides an opportunity to study the interaction between contemporaneous siliciclastic and carbonate deep-marine deposition. The Buduq Trough represents a sub-basin formed within the larger unstable post-rift margin of the EGC. Qualitative and quantitative facies analysis reveals that Upper Cretaceous stratigraphy of the Buduq Trough comprises a Cenomanian-Turonian siliciclastic submarine channel complex, which abruptly transitions into a Coniacian-Maastrichtian mixed-lobe succession. The Cenomanian – Turonian channels are shown to be entrenched in lows on the palaeo-seafloor, with the sequence entirely absent 10 km toward the west, where a Lower Cretaceous submarine landslide complex is suggested to have acted as a topographic barrier to deposition. By the Campanian this topography was largely healed, allowing deposition of the mixed-lobe succession across the Buduq Trough. Evidence for topography remains recorded through opposing palaeocurrents and frequent submarine landslides. The overall sequence is interpreted to represent abrupt Cenomanian-Turonian siliciclastic progradation, followed by ~Coniacian retrogradation, before a more gradual progradation in the Santonian-Maastrichtian. This deep-marine siliciclastic system interfingers with a calcareous system from the Coniacian onwards. These mixed lobe systems are different to siliciclastic-dominated systems in that they contain both siliciclastic and calcareous depositional elements, making classification of distal and proximal difficult using conventional terminology and complicating palaeogeographic interpretations. Modulation and remobilisation also occurs between the two contemporaneous systems, making stacking patterns difficult to decipher. The Buduq Trough is analogous in many ways to offshore The Gambia, NW Africa, and could be a suitable analogue for mixed deep-marine systems globally.