Spatial Transcriptomics Reveals Signatures of Histopathological Changes in Muscular Sarcoidosis
Hippolyte Lequain,
Cyril Dégletagne,
Nathalie Streichenberger
et al.
Abstract:Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma infiltrating various organs. The form with symptomatic muscular involvement is called muscular sarcoidosis. The impact of immune cells composing the granuloma on the skeletal muscle is misunderstood. Here, we investigated the granuloma–skeletal muscle interactions through spatial transcriptomics on two patients affected by muscular sarcoidosis. Five major transcriptomic clusters corresponding to perigranuloma, granuloma, and three … Show more
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