2014
DOI: 10.4161/cc.29156
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Spatial–temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness

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Cited by 73 publications
(90 citation statements)
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“…2 The results also suggest that drugs that target quiescent cancer cells are urgently needed. 1 In the present study, we demonstrate that dormant/quiescent cancer cells induce nascent tumor vessels after chemotherapy, allowing tumors to regrow rapidly after cessation of treatment. Chemotherapy-treated tumors had much more and deeper tumor vessels than control tumors and rapidly began regrowing after cessation of treatment.…”
Section: Introductionmentioning
confidence: 80%
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“…2 The results also suggest that drugs that target quiescent cancer cells are urgently needed. 1 In the present study, we demonstrate that dormant/quiescent cancer cells induce nascent tumor vessels after chemotherapy, allowing tumors to regrow rapidly after cessation of treatment. Chemotherapy-treated tumors had much more and deeper tumor vessels than control tumors and rapidly began regrowing after cessation of treatment.…”
Section: Introductionmentioning
confidence: 80%
“…1). 1 A tumor 7 d after implantation consisted of 15.3 § 2.4% quiescent cancer cells and 84.7 § 2.4% proliferating cancer cells. A tumor 14 d after implantation consisted of 52.4 § 3.5% quiescent cancer cells and 47.6 § 3.5% proliferating cancer cells.…”
Section: Resultsmentioning
confidence: 99%
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