Spatial–temporal-demographic and virological changes of hand, foot and mouth disease incidence after vaccination in a vulnerable region of China

Huang, Li Min; Wang, Ting; Liu, Xuxiang; Fu, Yuansheng; Zhang, Sichen; Chu, Qinshu; Nie, Tingyue; Tu, Houmian; Cheng, Jian; Fan, Yin‐Guang

doi:10.1186/s12889-022-13860-z

Cited by 3 publications

(2 citation statements)

References 39 publications

(33 reference statements)

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“…The D3 subgenotype is the predominant genotype that circulates all over the world, particularly in Southeast Asia and Europe in recent years (Figure 8). As reported previously in Anhui, Ningxia, Beijing, and Heilongjiang, [16][17][18] we suggest that these two strains in Zhengzhou have evolved in a common cycle with CVA6 strains from other parts of China, and that these strains may have multiple transmission chains. F I G U R E 5 (A, B) Red herpes could be seen on both hands and feet of the child.…”

Section: Evolutionary Characteristics Of Virus Strainssupporting

confidence: 83%

Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China

Chen,

et al. 2023

Journal of Medical Virology

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An increasing number of studies have reported that atypical hand, foot, and mouth disease (HFMD) is becoming a new concern for children's health. At present, there is no official definition for atypical HFMD, but some studies have defined that it occurs at anatomic sites not listed in the definition of HFMD issued by the World Health Organization. Several pathogens have been reported to cause atypical HFMD, such as Coxsackievirus (CV)A6. As one of the most prevalent enteroviruses in the world, CVA6 seems to affect a wider range of children and causes more severe and prolonged illness than other enteroviruses. The early lesions of atypical HFMD are very similar to the clinical presentations of other diseases, such as eczema, which poses a challenge for clinicians aiming to identify and diagnose HFMD in a timely manner. Here, we report on six atypical HFMD patients caused by recombinant CVA6 variants, and the atypical manifestations include eczema coxsackium, large herpes, rice‐like red papules and herpes, purpuric rash, and onychomadesis, as well as and large red herpes on scalp, perianal, testicles, shoulders and neck, and other atypical eruption sites, hoping to draw the attention of other pediatricians. This study will provide scientific guidance for timely diagnosis of HFMD to prevent serious complications.

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Section: Evolutionary Characteristics Of Virus Strainssupporting

confidence: 83%

Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China

Chen,

et al. 2023

Journal of Medical Virology

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“…The original publication of this article [ 1 ] contained an incorrect author name. The incorrect and correct name are shown below.…”

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confidence: 99%

Correction: Spatial–temporal-demographic and virological changes of hand, foot and mouth disease incidence after vaccination in a vulnerable region of China

et al. 2022

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Epidemiological characteristics and spatiotemporal clustering analysis of hand-foot-and-mouth disease in Dali between 2013 and 2021

Liu

Zhang

Liu

et al. 2023

Preprint

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Background: Hand-foot-and-mouth disease (HFMD) poses a global pediatric public health problem. There is no effective cure, so prevention and control of HFMD appears crucial. Spatiotemporal aggregation analysis allows exploration of disease occurrence, epidemic pattern, transmission rules, etiology and transmission risk, giving a basis for disease prevention and control, what information can provide in terms of the epidemiological characteristics of HFMD in Dali? Objectives: This study aimed to Combine with the spatiotemporal aggregation analysis, which augment scientific reference and provide theoretical guidance for prevention and control research into HFMD and other epidemic diseases. Methods: Infectious disease surveillance data and pathogen test results from the Dali Center for Disease Control and Prevention relating to HFMD were collated. An approach focusing on descriptive epidemiology and spatiotemporal clustering was adopted. Results: A total of 49 093 HFMD cases were reported in Dali between 2013 and 2021, giving a mean annual incidence of 150.90/100 000 and 2 793 out of 4 634 samples tested positive (60.27%). Annual incidence showed significant differences between years (Χ² = 2 614.63, p < 0.001) with the majority of cases occurring during the summer. Diaspora children (n = 32 374, 65.94%) aged between 0 to 6 years old were predominantly affected and incidence rate varied by sex with males more likely to be infected (Χ² = 755.65, p < 0.001). Yongping(437.43/100 000), Binchuan(344.78/100 000) and Dali City (294.10/100 000) showed the highest incidence rates with those of adjacent areas being relevant. Clusters were more likely to occur between 4/1-7/31 and 10/1-12/31 and data were gathered from Dali City, Yangbi, Binchuan, Yongping, Yunlong, Nanjian, Weishan and Heqing. Conclusions: HFMD in Dali was concentrated in the summer and predominantly affected preschool children. The highest incidences were found in Yunlong, Binchuan and Dali City. Incidence rates were correlated in time and space with dominant pathogens being CA16 and other EVs. The current data relating to the trend of the epidemic indicates that Dali public health departments may benefit from timely prevention and control measures.

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Spatial–temporal-demographic and virological changes of hand, foot and mouth disease incidence after vaccination in a vulnerable region of China

Cited by 3 publications

References 39 publications

Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China

Emerging concerns of atypical hand foot and mouth disease caused by recombinant Coxsackievirus A6 variants in Henan, China

Correction: Spatial–temporal-demographic and virological changes of hand, foot and mouth disease incidence after vaccination in a vulnerable region of China

Epidemiological characteristics and spatiotemporal clustering analysis of hand-foot-and-mouth disease in Dali between 2013 and 2021

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