Spatial suppression in visual motion perception is driven by inhibition: Evidence from MEG gamma oscillations

Orekhova, Elena V.; Rostovtseva, Ekaterina N.; Manyukhina, Viktoriya O.; Prokofiev, Andrey O; Obukhova, Tatiana S; Nikolaeva, Anastasia; Schneiderman, Justin F.; Stroganova, Tatiana A.

doi:10.1016/j.neuroimage.2020.116753

Cited by 17 publications

(36 citation statements)

References 76 publications

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“…The attenuation of the GR to moving high-contrast circular gratings caused by increasing their motion velocity (from 1.2 to 6.0 °/s) is a robust phenomenon that has been previously described in multiple studies [20][21][22]28,40 . To quantify this attenuation, we have previously introduced the Gamma Suppression Slope (GSS) index 28 .…”

Section: Meg Source Analysismentioning

confidence: 59%

“…The second is the low rank-order consistency of the visual GR power measured in different stimulation conditions. Indeed, in a recent study we report a lack of signi cant correlation between the power of GRs induced by static and fast-moving (6 °/sec) visual gratings 20 , despite a high intra-individual reliability of the GRs to both types of stimuli 21 . In other words, an individual might have a relatively high-power GR in one experimental condition and an average or even low-power GR in another.…”

Section: Introductionmentioning

confidence: 73%

“…In a series of recent studies we described the modulation of GR amplitude and frequency by changes in motion velocity of large high-contrast gratings [20][21][22] . In the transition from static to slow, and then to fast, visual motion resulted in bell-shaped changes in the GR power: it increased from the static to slow motion condition and then decreased with further increase in grating's drift rate.…”

Section: Introductionmentioning

confidence: 99%

“…The nonlinear changes in the human GR with increasing excitatory drive may therefore re ect such disproportional changes in excitation vs. inhibition strength in the visual cortex. A quantitative index of individual variability in intensity-related GR attenuation -'Gamma Suppression Slope' (GSS) -has been found to be individually stable across measurements separated by days or weeks 21 .…”

Section: Introductionmentioning

confidence: 99%

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Visual Gamma Oscillations Predict Sensory Sensitivity in Females as they do in Males

Manyukhina

Rostovtseva

Prokofyev

et al. 2021

Preprint

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Gamma oscillations are driven by local cortical excitatory (E) - inhibitory (I) loops and may help to characterize neural processing involving excitatory-inhibitory interactions. In the visual cortex reliable gamma oscillations can be recorded with magnetoencephalography (MEG) in the majority of individuals, which makes visual gamma an attractive candidate for biomarkers of brain disorders associated with E/I imbalance. Little is known, however, about if/how these oscillations reflect individual differences in neural excitability and associated sensory/perceptual phenomena. The power of visual gamma response (GR) changes nonlinearly with increasing stimulation intensity: it increases with transition from static to slowly drifting high-contrast grating and then attenuates with further increase in the drift rate. In a recent MEG study we found that the GR attenuation predicted sensitivity to sensory stimuli in everyday life in neurotypical adult men and in men with autism spectrum disorders. Here, we replicated these results in neurotypical female participants. The GR enhancement with transition from static to slowly drifting grating did not correlate significantly with the sensory sensitivity measures. These findings suggest that weak velocity-related attenuation of the GR is a reliable neural concomitant of visual hypersensitivity and that the degree of GR attenuation may provide useful information about E/I balance in the visual cortex.

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Section: Meg Source Analysismentioning

confidence: 59%

Section: Introductionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Visual Gamma Oscillations Predict Sensory Sensitivity in Females as they do in Males

Manyukhina

Rostovtseva

Prokofyev

et al. 2021

Preprint

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“…In addition, our modelling approach can be extended to contribute to a better understanding of the origin of MEG and BOLD signals. Examples of MEG datasets that could be used for that purpose are from (Orekhova et al, 2020(Orekhova et al, , 2018, who show gamma power saturation and decay as a function of stimulus velocity, and our own previous work. Better models of gamma may also help in better understanding the relationship between gamma, spiking and BOLD and can constitute the building blocks of models of the BOLD signal (Dahlqvist, Thomsen, Postnov, & Lauritzen, 2019;Takata et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Empirically Constrained Network Models for Contrast-dependent Modulation of Gamma Rhythm in V1

Zachariou

Roberts²,

Lowet

et al. 2019

Preprint

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Here we present experimentally-validated computational models of gamma rhythm and use these to investigate gamma oscillation instability. To this end, we extracted empirical constraints for PING (Pyramidal Interneuron Network Gamma) models from monkey single-unit and LFP responses recorded during contrast variation. These constraints implied weak rather than strong PING, connectivity between excitatory (E) and inhibitory (I) cells within specific bounds, and input strength variations that modulated E but not I cells.Constrained models showed valid behaviours, including gamma frequency increases with contrast and power saturation or decay at high contrasts. The route to gamma instability involved increased heterogeneity of E cells with increasing input triggering a breakdown of I cell pacemaker function. We illustrate the model's capacity to resolve disputes in the literature. Our work is relevant for the range of cognitive operations to which gamma oscillations contribute and could serve as a basis for future, more complex models.

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On the Development of Directed Acyclic Graphs in Differential Diagnostics of Pulmonary Diseases with the Help of Arterial Oscillogram Assessment

Martsenyuk

Vakulenko

Hryshchuk

et al. 2021

Mechanisms and Machine Science

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Spatial suppression in visual motion perception is driven by inhibition: Evidence from MEG gamma oscillations

Cited by 17 publications

References 76 publications

Visual Gamma Oscillations Predict Sensory Sensitivity in Females as they do in Males

Visual Gamma Oscillations Predict Sensory Sensitivity in Females as they do in Males

Empirically Constrained Network Models for Contrast-dependent Modulation of Gamma Rhythm in V1

On the Development of Directed Acyclic Graphs in Differential Diagnostics of Pulmonary Diseases with the Help of Arterial Oscillogram Assessment

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