Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine‐needle aspiration specimens

Abstract

BACKGROUND: Thyroid fine-needle aspiration (FNA) biopsy, the preoperative diagnostic standard of care for patients with thyroid nodules, has limitations. Spectral imaging captures visible light information that is beyond the capability of the human eye, potentially increasing the accuracy of FNA biopsy. In the current study, the authors demonstrated the feasibility of using spectral imaging in combination with automated spatial analysis based on trainable pattern recognition as an adjunct test for thyroid FNA classification by developing an algorithm that distinguishes between images of papillary thyroid carcinoma (PTC) and benign goiter (BG). METHODS: A multispectral camera was used to capture spectral images representing 100 cases of PTC and BG. Used in conjunction with commercial software, 10 cases were used as a training set to develop a ''classifier,'' a classification algorithm that segments digitized multispectral images into regions of PTC, BG, and ''nonfeature.'' This algorithm was used to generate a screening test and a diagnostic test that were validated on

Towards automated spectroscopic tissue classification in thyroid and parathyroid surgery

“…Several innovative optical techniques have been under investigation for their potential in differentiating benign from malignant cells in thyroid and parathyroid specimens: multispectral image analysis , Raman spectroscopy and elastic scattering spectroscopy . Fluorescence imaging after peripheral infusion of aminolevulinic acid or methylene blue is reported for intraoperative detection of parathyroid adenomas.…”

Congenital Hypogonadotropic Hypogonadism with Anosmia and Gorlin Features Caused by a PTCH1 Mutation Reveals a New Candidate Gene for Kallmann Syndrome

“…Pathophysiological links between KS and Waardenburg and CHARGE syndromes have been recently reinforced in studies using mouse models for sox10 and chd7 [7,60]. Similarly, several mouse models with natural or induced alterations in the murine orthologue ptch1 provide additional support for shared pathophysiological mechanisms underlying GGS/NBCCS an KS [61][62][63][64][65][66][67]. Sweet et al [61] first explored the reproductive phenotype of mice (termed mes at that time) carrying a spontaneous genetic abnormality in the ptch1 coding locus on chromosome 13, then called ptc [61,67].…”