Spatial reversal deficit in monkeys with amygdalohippocampal ablations

Mahut, Helen; Cordeau, J. Pierre

doi:10.1016/0014-4886(63)90023-2

Cited by 151 publications

(22 citation statements)

References 12 publications

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“…For example, Zola-Morgan and reported that lesions of the hippocampus (including the amygdala) seriously impaired the performance of monkeys on this task when the delay was 15 set but not when the delay was 8 set, and in a study by Mishkin and Pribram (1954), hippocampal damage was shown to have an adverse affect on delayed response leaming when there was no preoperative testing history but not when monkeys had extensive preoperative training. Conversely, in their studies of the effect of hippocampal or medial temporal lesions, Orbach et al (1960), Mahut and Cordeau (1963), Correll and Scoville (1967), and Mahut (197 1) appeared to indicate no deficit on the delayed spatial response task with O-l 5 set delays. However, careful reexamination of these results reveals that some of their subjects required more training and performed more poorly on the delayed response paradigm than did the control-lesioned monkeys.…”

Section: Lcgu As a Function Of Mnemonic Demandmentioning

confidence: 95%

“…The facilitation of metabolic activity in the hippocampus and dentate gyrus of the working-memory group parallels the findings of previous hippocampal lesion studies. With respect to the delayed spatial alternation task, lesions of the hippocampal formation, as well as lesions which more extensively involve the medial temporal lobe, have been shown to impair the performance of monkeys on this task when delays of 5 set or more are used, although individual variability due to differences in testing history, lesion size, or learning strategies has been noted (Orbach et al, 1960;Pribram et al, 1962;Mahut and Cordeau, 1963;Correll and Scoville, 1967;Waxler and Rosvold, 1970;Mahut, 197 1). The length ofthe delay, beyond a critical interval, however, may not potentiate the adverse effects of the lesion (Correll and Scoville, 1967).…”

Section: Lcgu As a Function Of Mnemonic Demandmentioning

confidence: 99%

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Activation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys

1988

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The 2-deoxyglucose method was used to examine metabolic activity in the hippocampus, dentate gyrus, and amygdala of rhesus monkeys performing working-memory and control tasks. A working-memory group was tested on 1 of 3 tasks requiring trial-by-trial updating of information: delayed spatial response, delayed spatial alternation, or delayed object alternation. A control group was tested either on an associative memory problem, visual pattern discrimination, or a sensory-motor task that did not have an explicit mnemonic component. Local cerebral glucose utilization (LCGU) in specific layers of the dentate gyrus and the CA1 and CA3 sectors of the hippocampus, as well as in 7 distinct nuclei of the amygdala, was measured and compared across groups. Metabolic rate in specific layers of the dentate gyrus and the CA3 and CA1 fields of the hippocampus was enhanced in the working-memory compared with the control group: LCGU was between 18 and 24% higher in the granule cell and molecular layers of the dentate gyrus and in the molecular and radiatum layers of CA1 and CA3 in the hippocampus. In contrast, no significant group differences in LCGU were found for any of the 7 amygdaloid nuclei examined: the lateral, lateral basal, medial basal, accessory basal, cortical, central, and medial nuclei. These results are consistent with previous evidence showing that lesions of the hippocampus affect memory selectively, producing deficits on some memory problems while sparing others. Our findings further suggest that working-memory may be a common denominator among those tasks that are sensitive to hippocampal damage in monkeys. The contribution of the amygdala to performance on memory tasks, on the other hand, appears to be independent of the specific type of memory process that is engaged.

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Section: Lcgu As a Function Of Mnemonic Demandmentioning

confidence: 95%

Section: Lcgu As a Function Of Mnemonic Demandmentioning

confidence: 99%

Activation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys

1988

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“…The fact that the rats with basolateral lesions were capable of learning the go-no-go discrimination and reversaI problem (Experiment III), and the cued alternation task (Experiment IVB) would be inconsistent with such an interpretation. Also inconsistent with this interpretation is the failure to find any deficit in the acquisition of a delayed response and several types of discrimination problems in monkeys with amygdaloid lesions (Mahut & Cordeau, 1963;Orbach et al, 1960;Schwartzbaum, 1965;Schwartzbaum & Pribram, 1960).…”

Section: Runway Performancementioning

confidence: 96%

“…Addi-(,1 tional evidence for perseveration in hippocampal animals cornes from deficits in alternation behavior (Lash, 1964: Pribram et al, 1962: Mahut & Cordeau, 1963. However, Kaplan's (1966) …”

Section: Hippocampusmentioning

confidence: 99%

Amygdaloid lesions and behavioral inhibition in the rat.

Pellegrino¹

1968

Journal of Comparative and Physiological Psychology

135

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Rats with bilateral lesions of the basolateral region of the amygdala were impaired in passive avoidance, DRL performance, and spatial alternations without cues, but not in visually cued spatial alternations or go-no-go visual discriminations and reversals. Except for a small deficit in passive avoidance, rats with lesions in the corticomedial region of the amygdala were not impaired in these tasks. Deficits produced by basolateral lesions can not readily be attributed to increased motivation for food or water. Results suggest that rats with basolateral amygdaloid lesions are unable to inhibit established responses when they must depend on information provided by internal cues.1 This report is based on a dissertation submitted to McGill University in partial fulfillment of the requirements for the PhD degree. The author wishes to thank his thesis adviser, R. B.

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“…As a consequence of deficits in an inhibitory mechanism, the hippocampally ablated animals are expected to show an obvious tendency to perseverate. Other investigators have attempted to characterize the behavioral changes following the hippocampal ablation as response perseveration (Kimble, 1963;Ellen & Wilson, 1963;Mahut &. Cordeau, 1963;Jarrard et al, 1964).…”

mentioning

confidence: 99%

Response Perseveration Following the Hippocampal Ablation in the Rat

Niki

1966

Jpn. Psychol. Res

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Spatial reversal deficit in monkeys with amygdalohippocampal ablations

Cited by 151 publications

References 12 publications

Activation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys

Activation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys

Amygdaloid lesions and behavioral inhibition in the rat.

Response Perseveration Following the Hippocampal Ablation in the Rat

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