Spatial representation by ramping activity of neurons in the retrohippocampal cortex

Tennant, Sarah Anne; Clark, Harry; Hawes, Ian; Tam, Wing; Hua, Junji; Yang, Weijia; Gerlei, Klára Z.; Wood, Emma R.; Nolan, Matthew F.

doi:10.1016/j.cub.2022.08.050

Cited by 8 publications

(18 citation statements)

References 82 publications

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“…A possible explanation for this dissociation is that the MEC might contain multiple sub-networks, with populations of grid cells and coherent non-grid cells sharing continuous attractor dynamics, while other populations of non-grid cells operate independently from the grid network. For example, non-grid cells may be differentially influenced by visual cues (Casali et al, 2018; Kinkhabwala et al, 2020) or could generate location representations through ramping profiles rather than discrete firing fields (Tennant et al, 2022). The presence in the MEC of functionally distinct grid and non-grid networks might also account for why manipulations that perturb grid cells selectively disrupt path integration-dependent behaviours (Gil et al, 2017), whereas manipulations that target layer 2 stellate cells, which include grid and non-grid cells, impair path integration-dependent and cued behaviours (Qin et al, 2018; Tennant et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…This could reflect additional mechanisms for the implementation of path integration, for example through ramping activity (cf. (Tennant et al, 2022)). Alternatively, mice could in principle estimate track location with a system that utilises information about distance travelled obtained from task-independent grid representations.…”

Section: Spatial Roles Of Grid Cells May Be Specific To Path Integrat...mentioning

confidence: 99%

“…Microdrive fabrication and surgical procedures were similar to our previous work (Gerlei et al, 2020;Tennant et al, 2022). Microdrives containing 4 tetrodes were built by threading 90% platinum, 10% iridium tetrode wires (18 µm HML-coated, Neuralynx) to an EIB-16 board (Neuralynx) via an inner cannula (21 gauge 9 mm long).…”

Section: Microdrive Fabrication and Surgical Proceduresmentioning

confidence: 99%

“…The behavioural set up, training procedures and recording approaches were similar to those described previously (Tennant et al, 2022(Tennant et al, , 2018. Mice were handled twice a day for 7 days following surgery.…”

Section: Behavioural and Electrophysiological Recordingmentioning

confidence: 99%

“…(Campbell et al, 2018; Domnisoru et al, 2013)), this is the only spatially localised cue available after initiation of a trial. Removal of this cue enables testing of whether the mice are able to use a path integration strategy, in which case they should continue to selectively stop in the reward zone, or a cue-based strategy in which case they should no longer stop selectively at the reward zone location (Figure 1C)(see also (Tennant et al, 2022, 2018). We find that during the task, grid cells can either be anchored to the track reference frame (‘task-anchored’), or can maintain a periodic firing pattern independent of the track reference frame (‘task-independent’).…”

Section: Introductionmentioning

confidence: 99%

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Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

Clark

Nolan

2023

Preprint

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Grid firing fields of neurons in the medial entorhinal cortex have been proposed as a neural substrate for spatial localisation and path integration. While there are strong theoretical arguments to support these roles, it has been challenging to directly test whether and when grid cells contribute to behaviours. Here, we investigate firing of grid cells during a task in which mice obtain rewards by recalling a location on a linear virtual track. We find that grid firing can either be anchored to the track, providing a code for position, or can instead encode distance travelled independent from the track position. Because engagement of these representations varied between and within sessions we were able to test whether positional grid firing predicts behaviour. We find that when a visual cue indicates the reward location, performance is similar regardless of whether grid cells encode position or distance. By contrast, in the absence of the visual cue, performance was substantially improved when grid cells encoded position compared to when they encoded distance. Our results suggest that positional anchoring of grid firing enhances performance of tasks that require path integration.

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Section: Discussionmentioning

confidence: 99%

Section: Spatial Roles Of Grid Cells May Be Specific To Path Integrat...mentioning

confidence: 99%

Section: Microdrive Fabrication and Surgical Proceduresmentioning

confidence: 99%

Section: Behavioural and Electrophysiological Recordingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

Clark

Nolan

2023

Preprint

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Mental navigation in the primate entorhinal cortex

Neupane,

Fiete,

Jazayeri

2024

Nature

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A cognitive map is a suitably structured representation that enables novel computations using previous experience; for example, planning a new route in a familiar space1. Work in mammals has found direct evidence for such representations in the presence of exogenous sensory inputs in both spatial2,3 and non-spatial domains4–10. Here we tested a foundational postulate of the original cognitive map theory1,11: that cognitive maps support endogenous computations without external input. We recorded from the entorhinal cortex of monkeys in a mental navigation task that required the monkeys to use a joystick to produce one-dimensional vectors between pairs of visual landmarks without seeing the intermediate landmarks. The ability of the monkeys to perform the task and generalize to new pairs indicated that they relied on a structured representation of the landmarks. Task-modulated neurons exhibited periodicity and ramping that matched the temporal structure of the landmarks and showed signatures of continuous attractor networks12,13. A continuous attractor network model of path integration14 augmented with a Hebbian-like learning mechanism provided an explanation of how the system could endogenously recall landmarks. The model also made an unexpected prediction that endogenous landmarks transiently slow path integration, reset the dynamics and thereby reduce variability. This prediction was borne out in a reanalysis of firing rate variability and behaviour. Our findings link the structured patterns of activity in the entorhinal cortex to the endogenous recruitment of a cognitive map during mental navigation.

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Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain

Hegarty,

Gruenhagen,

Johnson

et al. 2024

Commun Biol

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The telencephalon has undergone remarkable diversification and expansion throughout vertebrate evolution, exhibiting striking variations in structural and functional complexity. Nevertheless, fundamental features are shared across vertebrate taxa, such as the presence of distinct regions including the pallium, subpallium, and olfactory structures. Teleost fishes have a uniquely “everted” telencephalon, which has confounded comparisons of their brain regions to other vertebrates. Here we combine spatial transcriptomics and single nucleus RNA-sequencing to generate a spatially-resolved transcriptional atlas of the Mchenga conophorus cichlid fish telencephalon. We then compare cell-types and anatomical regions in the cichlid telencephalon with those in amphibians, reptiles, birds, and mammals. We uncover striking transcriptional similarities between cell-types in the fish telencephalon and subpallial, hippocampal, and cortical cell-types in tetrapods, and find support for partial eversion of the teleost telencephalon. Ultimately, our work lends new insights into the organization and evolution of conserved cell-types and regions in the vertebrate forebrain.

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Spatial representation by ramping activity of neurons in the retrohippocampal cortex

Cited by 8 publications

References 82 publications

Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

Mental navigation in the primate entorhinal cortex

Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain

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