Abstract:Changes in the spatial organization of bacterial chromosomes under stress conditions and its biological implications remain poorly understood. We mapped the structural landscape of wild-type and Δdcm E. colichromosomes under triclosan stress using Hi-C to identify triclosan-induced chromosomal interaction domains (CIDs). Two CIDs were common to the wild-type and Δdcm E. coli, including a CID with a common boundary atfabIgene, which encodes the triclosan target. All mutations and structural variants under tricl… Show more
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