Spatial proteomics identifies a spectrum of immune dysregulation in acquired bone marrow failure syndromes
Rachel M. Koldej,
Ashvind Prabahran,
Chin Wee Tan
et al.
Abstract:Poor graft function (PGF), manifested by multilineage cytopenias and complete donor chimerism post-allogeneic stem cell transplantation (alloSCT), and acquired aplastic anaemia (AA) are immune-mediated acquired bone marrow (BM) failure syndromes with a similar clinical presentation. In this study, we used spatial proteomics to compare the immunobiology of the BM microenvironment and identify common mechanisms of immune dysregulation under these conditions. Archival BM trephines from patients exhibited downregu… Show more
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