Spatial patterns of heterotopic ossification in fibrodysplasia ossificans progressiva correlate with anatomic temperature gradients

Wang, Haitao; Cunto, Carmen L. De; Pignolo, Robert J.; Kaplan, Frederick S.

doi:10.1016/j.bone.2021.115978

Cited by 1 publication

(1 citation statement)

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“…Pathways potentially involved in FOP heterotopic bone formation: Intriguingly, FOP HO development has been shown to be closely correlated with spatiotemporal patterns of human body infrared thermographs, suggesting that temperature responsive FOP connective tissue progenitor cells (CTPCs) may act as potent determinants of the anatomic distribution of HO in FOP [ 100 ]. Recently, vitamin D 3 has been raised as another potential modulator of BMP signaling, chondrogenesis, and possibly enhanced activin A expression.…”

Section: Activin A—a Complex Contributor To Fibrodysplasia Ossificans...mentioning

confidence: 99%

Immunologic Aspects in Fibrodysplasia Ossificans Progressiva

Diolintzi,

Pervin,

Hsiao

2024

Biomolecules

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Background: Inflammation is a major driver of heterotopic ossification (HO), a condition of abnormal bone growth in a site that is not normally mineralized. Purpose of review: This review will examine recent findings on the roles of inflammation and the immune system in fibrodysplasia ossificans progressiva (FOP). FOP is a genetic condition of aggressive and progressive HO formation. We also examine how inflammation may be a valuable target for the treatment of HO. Rationale/Recent findings: Multiple lines of evidence indicate a key role for the immune system in driving FOP pathogenesis. Critical cell types include macrophages, mast cells, and adaptive immune cells, working through hypoxia signaling pathways, stem cell differentiation signaling pathways, vascular regulatory pathways, and inflammatory cytokines. In addition, recent clinical reports suggest a potential role for immune modulators in the management of FOP. Future perspectives: The central role of inflammatory mediators in HO suggests that the immune system may be a common target for blocking HO in both FOP and non-genetic forms of HO. Future research focusing on the identification of novel inflammatory targets will help support the testing of potential therapies for FOP and other related conditions.

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Section: Activin A—a Complex Contributor To Fibrodysplasia Ossificans...mentioning

confidence: 99%