Spatial patterns of elevated magnetic susceptibility in progressive apraxia of speech

Satoh, Ryota; Arani, Arvin; Senjem, Matthew L.; Duffy, Joseph R.; Clark, Heather M.; Utianski, Rene L.; Botha, Hugo; Machulda, Mary M.; Jack, Clifford R.; Whitwell, Jennifer L.; Josephs, Keith A.

doi:10.1016/j.nicl.2023.103394

Cited by 3 publications

(8 citation statements)

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“…We hypothesize that some cortical variants may show changes in cortical susceptibility because our group recently found that patients with progressive apraxia of speech, which is strongly associated with PSP-speech/language, 59 had greater susceptibility than control subjects in the white matter precentral gyrus. 33 The strength of this study is the novelty of applying QSM to the different PSP variants because, to our knowledge, no studies have addressed the susceptibility differences between different PSP clinical variants, PD, and CBS by using QSM. One of the limitations is that the number of patients is unbalanced between groups, and some groups had relatively small numbers of patients (eg, n = 4 in PSP-PI).…”

Section: Discussionmentioning

confidence: 99%

“…All subjects underwent a standardized MRI protocol on a 3‐Tesla scanner (Magnetom Prisma; Siemens Healthineers, Erlangen, Germany), including a 3D magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence and a 3D multiecho gradient‐echo sequence. The imaging protocol and sequence parameters were the same as in previous studies 32,33 . The gradient‐echo sequence parameters were repetition time of 28.0 ms; echo times of 6.7, 10.6, 14.5, 18.4, and 22.4 ms; flip angle of 15°; a 20‐cm field of view, in‐plane acquisition matrix of 384 × 269, slice number of 88; slice thickness of 1.8 mm; and generalized autocalibrating partially parallel acquisitions (GRAPPA) acceleration factor of 2.…”

Section: Methodsmentioning

confidence: 99%

“…MRIs were processed using the same methods as previously reported 33 . In brief, T1‐weighted images from the MPRAGE scan were segmented into gray and white matter using templates and settings from the Mayo Clinic Adult Lifespan Template (MCALT).…”

Section: Methodsmentioning

confidence: 99%

“…The imaging protocol and sequence parameters were the same as in previous studies. 32,33 The gradient-echo sequence parameters were repetition time of 28.0 ms; echo times of 6.7, 10.6, 14.5, 18.4, and 22.4 ms; flip angle of 15 ; a 20-cm field of view, in-plane acquisition matrix of 384 Â 269, slice number of 88; slice thickness of 1.8 mm; and generalized autocalibrating partially parallel acquisitions (GRAPPA) acceleration factor of 2.…”

Section: Mri Analysismentioning

confidence: 99%

“…MRIs were processed using the same methods as previously reported. 33 In brief, T1-weighted images from the MPRAGE scan were segmented into gray and white matter using templates and settings from the Mayo Clinic Adult Lifespan Template (MCALT). Brain atlases for region-of-interest (ROI) analysis were nonlinearly registered from the MCALT space to each subject space using Advanced Normalization Tools.…”

Section: Mri Analysismentioning

confidence: 99%

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Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome

Satoh,

Weigand,

Pham

et al. 2023

Movement Disorders

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BackgroundPrevious studies have shown that magnetic susceptibility is increased in several subcortical regions in progressive supranuclear palsy (PSP). However, it is still unclear how subcortical and cortical susceptibilities vary across different PSP variants, Parkinson's disease (PD), and corticobasal syndrome (CBS).ObjectiveThis study aims to clarify the susceptibility profiles in the subcortical and cortical regions in different PSP variants, PD, and CBS.MethodsSixty‐four patients, 20 PSP‐Richardson syndrome (PSP‐RS), 9 PSP‐parkinsonism (PSP‐P), 7 PSP‐progressive gait freezing, 4 PSP‐postural instability, 11 PD, and 13 CBS, and 20 cognitively normal control subjects underwent a 3‐Tesla magnetic resonance imaging scan to reconstruct quantitative susceptibility maps. Region‐of‐interest analysis was performed to obtain susceptibility in several subcortical and cortical regions. Bayesian linear mixed effect models were used to estimate susceptibility within group and differences between groups.ResultsIn the subcortical regions, patients with PSP‐RS and PSP‐P showed greater susceptibility than control subjects in the pallidum, substantia nigra, red nucleus, and cerebellar dentate (P < 0.05). Patients with PSP‐RS also showed greater susceptibility than patients with PSP‐progressive gait freezing, PD, and CBS in the red nucleus and cerebellar dentate, and patients with PSP‐P showed greater susceptibility than PD in the red nucleus. Patients with PSP‐postural instability and CBS showed greater susceptibility than control subjects in the pallidum and substantia nigra. No significant differences were observed in any cortical region.ConclusionsThe PSP variants and CBS had different patterns of magnetic susceptibility in the subcortical regions. The findings will contribute to our understanding about iron profiles and pathophysiology of PSP and may provide a potential biomarker to differentiate PSP variants, PD, and CBS. © 2023 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Mri Analysismentioning

confidence: 99%

Section: Mri Analysismentioning

confidence: 99%

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