Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease

Dierks, Thomas; Jelić, Vesna; Pascual-Marqui, Roberto D.; Wahlund, Lars‐Olof; Julin, Per; Linden, David Edmund Johannes; Maurer, K.; Winblad, Bengt; Nordberg, Agneta

doi:10.1016/s1388-2457(00)00427-2

Cited by 272 publications

(229 citation statements)

References 27 publications

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“…For instance, excellent localization agreement has been reported in multimodal imaging studies with functional MRI (Mulert et al, 2004;Vitacco et al, 2002), structural MRI (Worrell et al, 2000), and PET (e.g. Dierks et al, 2000;Zumsteg et al, 2005). Further validation based on accepting as "ground truth" the information provided by intracranial recordings in humans has been reported in a number of papers (e.g.…”

Section: Data Conditioningmentioning

confidence: 92%

Reduced functional connectivity between cortical sources in five meditation traditions detected with lagged coherence using EEG tomography

Lehmann¹,

Faber²,

Tei

et al. 2012

NeuroImage

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137

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Brain functional states are established by functional connectivities between brain regions. In experienced meditators (13 Tibetan Buddhists, 15 QiGong, 14 Sahaja Yoga, 14 Ananda Marga Yoga, 15 Zen), 19-channel EEG was recorded before, during and after that meditation exercise which their respective tradition regards as route to the most desirable meditative state. The head surface EEG data were recomputed (sLORETA) into 19 cortical regional source model time series. All 171 functional connectivities between regions were computed as 'lagged coherence' for the eight EEG frequency bands (delta through gamma). This analysis removes ambiguities of localization, volume conduction-induced inflation of coherence, and reference-dependence. All significant differences (corrected for multiple testing) between meditation compared to no-task rest before and after meditation showed lower coherence during meditation, in all five traditions and eight (inhibitory as well as excitatory) frequency bands. Conventional coherence between the original head surface EEG time series very predominantly also showed reduced coherence during meditation. The topography of the functional connectivities was examined via PCAbased computation of principal connectivities. When going into and out of meditation, significantly different connectivities revealed clearly different topographies in the delta frequency band and minor differences in the beta-2 band. The globally reduced functional interdependence between brain regions in meditation suggests that interaction between the self process functions is minimized, and that constraints on the self process by other processes are minimized, thereby leading to the subjective experience of noninvolvement, detachment and letting go, as well as of all-oneness and dissolution of ego borders during meditation. AbstractBrain functional states are established by functional connectivities between brain regions. In experienced meditators (13 Tibetan Buddhists, 15 QiGong, 14 Sahaja Yoga, 14 Ananda Marga Yoga, 15 Zen), 19-channel EEG was recorded before, during and after that meditation exercise which their respective tradition regards as route to the most desirable meditative state. The head surface EEG data were recomputed (sLORETA) into 19 cortical regional source model time series. All 171 functional connectivities between regionswere computed as 'lagged coherence' for the eight EEG frequency bands (delta through gamma). This analysis removes ambiguities of localization, volume conduction-induced inflation of coherence, and reference-dependence. All significant differences (corrected for multiple testing) between meditation compared to no-task rest before and after meditation showed lower coherence during meditation, in all five traditions and eight (inhibitory as well as excitatory) frequency bands. Conventional coherence between the original head surface EEG time series very predominantly also showed reduced coherence during meditation. The topography of the functional connectivities was examined ...

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Section: Data Conditioningmentioning

confidence: 92%

Reduced functional connectivity between cortical sources in five meditation traditions detected with lagged coherence using EEG tomography

Lehmann¹,

Faber²,

Tei

et al. 2012

NeuroImage

Self Cite

137

View full text Add to dashboard Cite

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“…Keeping these considerations in mind, it is unlikely that the differences in LORETA solutions between the groups (Responder, Non-Responder) depended on differences in brain atrophy, although such changes can be crucial from a functional point of view as demonstrated in subjects with mild cognitive impairment (Visser et al, 1999). Indeed, it is a widely accepted procedure -within the LORETA frame -to use a template head model in the investigation of EEG rhythms in physiological and pathological aging (Anderer et al, 1998a(Anderer et al, ,b, 2003Dierks et al, 2000;Huang et al, 2002;Saletu et al, 2002;Goforth et al, 2004;Babiloni et al, 2004;Cincotti et al, 2004).…”

Section: Cortical Source Analysis Of the Eeg Rhythms By Loretamentioning

confidence: 99%

Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders

Cassetta²,

et al. 2006

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“…analysis. The brain volume changes are measured by M.R.I (Dierks et al 2000;Sunderland et al 2003;Maheswaran et al 2009;Luckhaus et al 2010) 9 .…”

Section: Introductionmentioning

confidence: 99%

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

Mahajan

Votruba

2017

Acta Ophthalmologica

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Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of senile dementia. It impairs the quality of life of a person and their family, posing a serious economic and social threat in developed countries. The fact that the diagnosis can only be definitively made post‐mortem, or when the disease is fairly advanced, presents a serious problem if novel therapeutic interventions are to be devised and used early in the course of the disease. There is therefore a pressing need for more sensitive and specific diagnostic tests with which we can detect AD in the preclinical stage. The tau proteins and beta‐amyloid proteins start to accumulate 20 years before the symptoms begin to manifest. Detecting them in the preclinical stage would be a potential breakthrough in the management of AD. A high degree of clinical suspicion is needed to correlate problems in cognition with the changes in the eye, particularly the retina, pupil and ocular movements, so that the disease can be detected early and managed in the prodromal phase. In this systematic review, we ask the question whether the retina can be used to make a specific and early diagnosis of AD.

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Spatial pattern of cerebral glucose metabolism (PET) correlates with localization of intracerebral EEG-generators in Alzheimer's disease

Cited by 272 publications

References 27 publications

Reduced functional connectivity between cortical sources in five meditation traditions detected with lagged coherence using EEG tomography

Reduced functional connectivity between cortical sources in five meditation traditions detected with lagged coherence using EEG tomography

Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders

Can the retina be used to diagnose and plot the progression of Alzheimer's disease?

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