Spatial organization within a niche as a determinant of stem-cell fate

Rompolas, Panteleimon; Mesa, Kailin R.; Greco, Valentina

doi:10.1038/nature12602

Cited by 351 publications

(423 citation statements)

References 48 publications

(60 reference statements)

Supporting

Mentioning

415

Contrasting

Order By: Relevance

“…The dogma suggests a strict cellular hierarchy within tissues in which somatic stem cells are able to both self-renew and asymmetrically divide leading to the generation of progenitors which can fully differentiate into the cell types resident in the tissue. This cellular hierarchy has been challenged by recent studies (Mannik et al 2010, Rompolas et al 2013, Tata et al 2013 which have shown that differentiated epithelial cells can dedifferentiate to assume the functions of the somatic stem cell. In addition, induction of epithelial-mesenchymal transition (EMT) by TGFb or by other means has been shown to increase the stemness of both mammary (Mani et al 2008) and ovarian surface epithelial cells .…”

Section: Somatic Stem Cells and Epithelial Cell Plasticitymentioning

confidence: 92%

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Garson¹,

Vanderhyden²

2015

Reproduction

View full text Add to dashboard Cite

The lack of significant progress in the treatment of epithelial ovarian cancer (EOC) underscores the need to gain a better understanding of the processes that lead to chemoresistance and recurrence. The cancer stem cell (CSC) hypothesis offers an attractive explanation of how a subpopulation of cells within a patient's tumour might remain refractory to treatment and subsequently form the basis of recurrent chemoresistant disease. This review examines the literature defining somatic stem cells of the ovary and fallopian tube, two tissues that give rise to EOC. In addition, considerable research has been reviewed, that has identified subpopulations of EOC cells, based on marker expression (CD133, CD44, CD117, CD24, epithelial cell adhesion molecule, LY6A, ALDH1 and side population (SP)), which are enriched for tumour initiating cells (TICs). While many studies identified either CD133 or CD44 as markers useful for enriching for TICs, there is little consensus. This suggests that EOC cells may have a phenotypic plasticity that may preclude the identification of universal markers defining a CSC. The assay that forms the basis of quantifying TICs is the xenograft assay. Considerable controversy surrounds the xenograft assay and it is essential that some of the potential limitations be examined in this review. Highlighting such limitations or weaknesses is required to properly evaluate data and broaden our interpretation of potential mechanisms that might be contributing to the pathogenesis of ovarian cancer.

show abstract

Section: Somatic Stem Cells and Epithelial Cell Plasticitymentioning

confidence: 92%

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Garson¹,

Vanderhyden²

2015

Reproduction

View full text Add to dashboard Cite

show abstract

“…These findings suggest that even after assimilating an "IFE-like" phenotype, HFderived cells may still differ subtly from true IFE-derived cells, perhaps in the degree of Notch activation. Further studies, potentially incorporating lineage tracing and live cell imaging, 42 will be required to "flesh out" these and other interesting questions regarding wounding and cell fate.…”

Section: Discussionmentioning

confidence: 99%

Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration

2015

View full text Add to dashboard Cite

Upon wounding, multiple stem cell populations in the hair follicle (HF) and interfollicular epidermis (IFE) converge at the site of injury. Although these cells can contribute permanently to the regenerating epithelium, it remains unclear whether these contributions vary among cells originating from diverse compartments in the skin. By comparing the fates of several keratinocyte lineages, we observed here an initial decrease in both HF-and IFE-derived cells within the transient acanthotic layers of the regenerating epithelium. At the same time, the relative abundance of early-arriving IFE-derived cells specifically in the wound basal layer declined as later-arriving HF-derived cells entered the site of injury. Although laggard bulge-derived cells were typically constrained at the regenerative periphery, these cells persisted in the wound basal layer. Finally, suppressing Notch enabled IFE-derived cells to out-compete HF-derived cells. Taken together, these findings indicate that IFE-, HF-and bulge-derived cells make distinct contributions to regeneration over time. Furthermore, we speculate that extrinsic, non-genetic factors such as spatial constraint, distance from the wound, and basal versus suprabasal position may largely determine whether a cell ultimately persists.

show abstract

“…The mechanism for this switch is unknown. It was proposed that stem cell characteristics are provided by the cell environment as opposed to endogenous cell properties (Rompolas et al 2013), and that damage to their niche depletes the hair follicle stem cell population (Matsumura et al 2016). This interesting possibility could have important implications for cutaneous wound healing since damage to the extracellular matrix is a hallmark of skin aging (Rittié and Fisher 2015).…”

Section: Stem Cell Response To Woundingmentioning

confidence: 99%

Cellular mechanisms of skin repair in humans and other mammals

Rittié

2016

J. Cell Commun. Signal.

228

172

View full text Add to dashboard Cite

The increased incidence of non-healing skin wounds in developed societies has prompted tremendous research efforts on the complex process known as Bwound healing^. Unfortunately, the weak relevance of modern wound healing research to human health continues to be a matter of concern. This review summarizes the current knowledge of the cellular mechanisms that mediate wound closure in the skin of humans and laboratory animals. The author highlights the anatomical singularities of human skin vs. the skin of other mammals commonly used for wound healing research (i.e. as mice, rats, rabbits, and pigs), and discusses the roles of stem cells, myofibroblasts, and the matrix environment in the repair process. The majority of this review focuses on reepithelialization and wound closure. Other aspects of wound healing (e.g. inflammation, fibrous healing) are referred to when relevant to the main topic. This review aims at providing the reader with a clear understanding of the similarities and differences that have been reported over the past 100 years between the healing of human wounds and that of other mammals.

show abstract

Spatial organization within a niche as a determinant of stem-cell fate

Cited by 351 publications

References 48 publications

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm

Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration

Cellular mechanisms of skin repair in humans and other mammals

Contact Info

Product

Resources

About