Spatial organization of peptide nanotubes for electrochemical devices

Micro- and nano-sized peptidic assemblies prepared via solid-vapor approach: Morphological and spectroscopic aspects

“…XRD studies have suggested the existence of both hexagonal and orthorhombic lattices for diphenylalanine-based assemblies [30,49,50]. The hexagonal geometry corresponds to a more packed unit cell that contains a larger number of elements; the unit cell therefore exhibits more vibrational modes.…”

Novel method for prediction of micro/nanostructures of diphenylalanine dipeptide based on semiempirical thermodynamic study

“…The reversed phase chromatography was carried out using a C-18 column at an isocratic condition of 50% acetonitrile in 50% TFA (0.01%)/deionized water. Other methods for HPLC analysis of the dipeptide have also been developed in the literature [8,10], but this method has the advantage of sharp peaks at high dilutions. The solubility measurements have been repeated three times to be sure of the reproducibility of the results.…”

“…Thus, the solubility prediction of diphenylalanine dipeptide has been developed based on these models to gain a better understanding of the hierarchal self-assembly of this structural motif of Alzheimer ␤-amyloid polypeptide in water [5]. The self-assembly of this dipeptide in various micro/nanostructures with functional and structural properties caused it to be utilized in current and emerging applications as energy storage [6], biosensing [7], nanotemplates/nanoreactors [5,8], catalyst supports/adsorbents [9], and microelectronics [10]. The self-assembly of the dipeptide is under a crystallization process so that various micro/nanostructures of the dipeptide will be formed under different environments [9,11].…”

Self–Assembled Peptide Nanostructures for Biomedical Applications: Advantages and Challenges

“…Enzyme-modified peptide nanotubes have been utilized for the detection of compounds of biomedical relevance such as glucose, ethanol, or hydrogen peroxide as demonstrated by several groups. The enzymes were connected to the self-assembled peptide nanostructures through different matrices such as poly(allylamine hydrochloride) (Cipriano et al, 2010) or glutaraldehyde . Finally the modified peptide nanotubes were immobilized on the surface of metallic electrodes using polymer matrices like polyethyleneimine.…”

“…These applications have been reviewed in numerous articles (Aggeli et al, 2001, Gao & Matsui, 2005, Gazit, 2007, Hauser & Zhang, 2010, Kyle et al, 2010, Kyle et al, 2008, Rajagopal & Schneider, 2004, Scanlon & Aggeli, 2008, Woolfson & Ryadnov, 2006, Yan et al, 2010, and a detailed description of some of these applications has already been given in this chapter. In order to provide a broader vision of the possibilities of using these biological nanostructures with biomedical purposes, a list of different self-assembled peptide nanostructures is presented in (Cho et al, 2008) Nanotubes Glucose, ethanol and hydrogen peroxide detection Nanotubes Antiviral agent (Horne et al, 2005) Nanotubes Controlled drug release (Chen et al, 2011) Nanotubes Hydrogen peroxide detection (Cipriano et al, 2010) Nanotubes Drug delivery (von Maltzahn et al, 2003) Nanofibers Copper detection (Viguier et al, 2011) Nanofibers Dopamine detection (Sasso et al, 2011) Nanofibers Yersinia pestis detection (Men et al, 2010) Nanofibers Glucose detection (Yang et al, 2009) …”