Spatial navigation in elderly healthy subjects, amnestic and non amnestic MCI patients

Rusconi, Maria Luisa; Suardi, Angelocarlo; Zanetti, Marina; Rozzini, Luca

doi:10.1016/j.jns.2015.10.010

Cited by 37 publications

(42 citation statements)

References 55 publications

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“…The association of spatial navigation with pre-dementia syndromes is also supported by previous cross-sectional clinical, neuroimaging and biomarker studies. [3–5, 7, 8, 27] For instance, in a key series of studies, Czech researchers examined spatial navigation using a human version of the Morris water maze. [5] Participants were asked to mark an invisible target inside a small blue velvet covered circular arena.…”

Section: Discussionmentioning

confidence: 99%

“…Spatial navigational difficulties are seen in early clinical stages of AD, and are even reported in pre-dementia syndromes such as Mild Cognitive Impairment syndrome (MCI). [4–7] Navigational impairments, especially those involving exocentric navigation, have a similar pattern in patients with MCI and AD. [7, 8] These observations suggest that spatial navigation skills may be impaired early in the course of brain diseases such as AD, and could be a marker of future clinical progression of dementias.…”

Section: Introduction1mentioning

confidence: 99%

“…[4–7] Navigational impairments, especially those involving exocentric navigation, have a similar pattern in patients with MCI and AD. [7, 8] These observations suggest that spatial navigation skills may be impaired early in the course of brain diseases such as AD, and could be a marker of future clinical progression of dementias. However, longitudinal studies of the relationship of navigational skills with cognitive decline are rare.…”

Section: Introduction1mentioning

confidence: 99%

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Spatial navigation and risk of cognitive impairment: A prospective cohort study

Verghese

Lipton

Ayers

2017

Alzheimer's & Dementia

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INTRODUCTION Spatial navigation deficits are reported in dementia, but their temporal relationship to cognitive decline is not established. METHODS Prospective cohort study in 442 non-demented adults (mean age 79.9 years). Spatial navigation measured with the Floor Maze Test, and reported as immediate maze time (IMT) and delayed maze time (DMT). Pre-dementia syndromes, Mild Cognitive Impairment (MCI) and Motoric Cognitive Risk (MCR) syndromes, were primary outcomes. RESULTS Over a mean follow-up of 16.5 ± 13.7 months, 41 participants developed MCI and 30 MCR. In Cox models adjusted for age, sex, education, cognitive status, comorbid illnesses, and maze errors, a 10-second increment on IMT predicted incident MCI (adjusted hazard ratio [aHR] 1.25; 95% CI 1.06 to 1.48) and MCR (aHR 1.53; 95% CI 1.23 to 1.90). DMT predicted MCR but not MCI. DISCUSSION Spatial navigation performance predicted pre-dementia syndromes in aging, and implicates navigational impairments as an early feature in dementias.

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Section: Discussionmentioning

confidence: 99%

Section: Introduction1mentioning

confidence: 99%

Section: Introduction1mentioning

confidence: 99%

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Spatial navigation and risk of cognitive impairment: A prospective cohort study

Verghese

Lipton

Ayers

2017

Alzheimer's & Dementia

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“…Neuropathological changes, such as tau-deposits, synaptic dysfunction, and neuronal loss, manifest very early in critical hubs of the human spatial navigation network such as the mesiotemporal lobe (i.e., hippocampus and entorhinal cortex) and RSC (Braak et al, 1993;Braak, 1995, 1998;Vlček and Laczó, 2014). Research in the last decades revealed that navigation deficits can be already found in patients with amnestic mild cognitive impairment (aMCI), which is thought to be a pre-stage of impeding dementia (Hort et al, 2007;Laczó et al, 2009Laczó et al, , 2010Lithfous et al, 2013;Vlček and Laczó, 2014;Rusconi et al, 2015;Kim J. W. et al, 2017). Spatial navigation testing, therefore, has great potential for the early diagnosis of aMCI/AD in pre-symptomatic stages (Coughlan et al, 2018).…”

Section: Neurodegenerative Disorders: Mild Cognitive Impairment and Amentioning

confidence: 99%

Testing Navigation in Real Space: Contributions to Understanding the Physiology and Pathology of Human Navigation Control

Schöberl

Zwergal

Brandt

2020

Front. Neural Circuits

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Successful navigation relies on the flexible and appropriate use of metric representations of space or topological knowledge of the environment. Spatial dimensions (2D vs. 3D), spatial scales (vista-scale vs. large-scale environments) and the abundance of visual landmarks critically affect navigation performance and behavior in healthy human subjects. Virtual reality (VR)-based navigation paradigms in stationary position have given insight into the major navigational strategies, namely egocentric (body-centered) and allocentric (world-centered), and the cerebral control of navigation. However, VR approaches are biased towards optic flow and visual landmark processing. This major limitation can be overcome to some extent by increasingly immersive and realistic VR setups (including large-screen projections, eye tracking and use of head-mounted camera systems). However, the highly immersive VR settings are difficult to apply particularly to older subjects and patients with neurological disorders because of cybersickness and difficulties with learning and conducting the tasks. Therefore, a need for the development of novel spatial tasks in real space exists, which allows a synchronous analysis of navigational behavior, strategy, visual explorations and navigation-induced brain activation patterns. This review summarizes recent findings from real space navigation studies in healthy subjects and patients with different cognitive and sensory neurological disorders. Advantages and limitations of real space navigation testing and different VR-based navigation paradigms are discussed in view of potential future applications in clinical neurology.

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“…Ориентация в пространстве -это сложная многокомпонентная функция, обеспечивающая возможность определения своего местонахождения и траектории передвижения относительно других объектов внешнего мира [1][2][3]. Под «топографической дезориентацией» понимают нарушение способности больного узнавать местность и ее ориентиры, распознавать свое положение в пространстве, находить ранее знакомые маршруты и запоминать новые, использовать карту для ориентации [4][5][6][7][8][9].…”

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Topographical Disorientation in Patients with Brain Impairment

Grigoryeva¹,

Тихомиров²

2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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В статье описаны симптомы, патогенез, варианты топографической дезориентации. Представлены методы диагностики и реабилитации больных. Сделан вывод, что уточнение варианта топографической дезориентации и определение стратегии компенсации этого расстройства имеет большое значение для совершенствования нейрореабилитации больных с инсультами и другими очаговыми поражениями головного мозга.

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Spatial navigation in elderly healthy subjects, amnestic and non amnestic MCI patients

Cited by 37 publications

References 55 publications

Spatial navigation and risk of cognitive impairment: A prospective cohort study

Spatial navigation and risk of cognitive impairment: A prospective cohort study

Testing Navigation in Real Space: Contributions to Understanding the Physiology and Pathology of Human Navigation Control

Topographical Disorientation in Patients with Brain Impairment

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