Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

Coughlan, Gillian; Laczó, Jan; Hort, Jakub; Minihane, Anne‐Marie; Hornberger, Michael

doi:10.1038/s41582-018-0031-x

Cited by 347 publications

(385 citation statements)

References 146 publications

(166 reference statements)

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“…This is consistent with cross‐sectional findings of a significant deficit in CM, but not RL, in individuals in the preclinical AD continuum . Differential utility of CM measures is also consistent with neuropathology occurring early in CM‐relevant brain regions, such as entorhinal cortex and hippocampus …”

Section: Discussionsupporting

confidence: 82%

“…In a clinically heterogenous sample, with individuals ranging from clinically normal to mild symptomatic AD, both CM and RL predicted clinical progression and discriminated between progressors and nonprogressors. This is consistent with progressive involvement of hippocampal and striatal circuits with disease progression, as well as with deficits in both CM and RL in symptomatic AD . Thus, when seeking to predict clinical progression in individuals with varying levels of clinical impairment, deficits in multiple aspects of spatial navigation may serve to predict later disease progression.…”

Section: Discussionsupporting

confidence: 67%

“…This interest is consistent with amyloid and tau deposition, and volumetric declines, occurring early in brain regions that subserve navigation . For example, hippocampal place and entorhinal grid cells support spatial navigation, with evidence of AD‐related dysfunction in these neuronal substrates …”

Section: Introductionsupporting

confidence: 64%

“…There is emerging interest in targeting spatial navigation abilities that may prove more sensitive to preclinical AD than current psychometric measures used in identifying MCI and symptomatic AD . This interest is consistent with amyloid and tau deposition, and volumetric declines, occurring early in brain regions that subserve navigation . For example, hippocampal place and entorhinal grid cells support spatial navigation, with evidence of AD‐related dysfunction in these neuronal substrates …”

Section: Introductionmentioning

confidence: 98%

“…15,16 This interest is consistent with amyloid and tau deposition, and volumetric declines, occurring early in brain regions that subserve navigation. 7,17,18 For example, hippocampal place and entorhinal grid cells support spatial navigation, 19 with evidence of AD-related dysfunction in these neuronal substrates. 18 Deficits in multiple aspects of spatial navigation are consistently observed in MCI and symptomatic AD, 18,20 including impairments in route learning (RL) and cognitive mapping (CM).…”

Section: Introductionmentioning

confidence: 99%

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Spatial navigation ability predicts progression of dementia symptomatology

Levine

Allison

Stojanovic

et al. 2020

Alzheimer's & Dementia

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Introduction Spatial navigation deficits are observed in Alzheimer's disease cross‐sectionally, but prediction of longitudinal clinical decline has been less examined. Methods Cognitive mapping (CM) was assessed in 95 participants and route learning (RL) was assessed in 65 participants at baseline. Clinical progression over an average of 4 to 5 years was assessed using the clinical dementia rating (CDR) scale. Relative predictive ability was compared to episodic memory, hippocampus, and cerebrospinal fluid biomarkers (phosphorylated tau/amyloid β 42 (ptau181/Aβ42) ratio). Results CM and RL were predictors of clinical progression (P’s < 0.032). All measures, except RL‐Learning remained predictors with episodic memory in models (P’s < 0.048). Only RL‐Retrieval remained a predictor when ptau181/Aβ42 was included (P < 0.001). CM interacted with hippocampus and ptau181/Aβ42 in prediction (P’s < 0.013). CM, RL, and episodic memory evidenced strong diagnostic accuracy (area under the curve (AUC) = 0.894, 0.794, and 0.735, respectively); CM tended to perform better than episodic memory (P = 0.056). Discussion Baseline spatial navigation performance may be appropriate for assessing risk of clinical progression.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 67%

Section: Introductionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spatial navigation ability predicts progression of dementia symptomatology

Levine

Allison

Stojanovic

et al. 2020

Alzheimer's & Dementia

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A unified brain system of orientation and its disruption in Alzheimer’s disease

Dafni-Merom

Peters-Founshtein

Kahana-Merhavi

et al. 2019

Ann Clin Transl Neurol

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ObjectiveTo investigate whether a unified brain system manages one’s orientation to different places, events and people in one’s environment, and test the hypothesis that failure of this system (disorientation) is an early sign of Alzheimer’s disease (AD).MethodsA total of 46 participants (patients along the AD continuum and cognitively normal control subjects) were tested in a personalized, ecologically valid task of orientation relating to the participant’s own world in space, time and person under high–density electroencephalography. As a first step, we used evoked potential mapping to search for brain topography correlated with participants’ performance in orientating themselves to different places (space), events (time) and people (person) (Experiment 1). We then compared behavioral and electrophysiological changes in patients along the AD continuum (Experiment 2).ResultsWe identified a specific brain topography (“orientation map”) that was active for orientation in space, time and person in correlation to participants’ performance. Both performance and the map’s strength gradually decreased from health to mild cognitive impairment (MCI) and from MCI to AD. Another map, immediately preceding the orientation map, showed the longest activity in patients with MCI, significantly more than both patients with AD and cognitively normal controls.InterpretationOur findings demonstrate that the same brain topography accounts for orientation in the different domains of space, time and person and provide a nexus between deterioration in patients’ orientation with the aggravation of Alzheimer’s disease.

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Using visual scene memory accuracy as a predictor of spatial navigation performance

Lovegrove

Baumann

2021

Applied Cognitive Psychology

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Spatial navigation is a fundamental cognitive function essential for daily life. Navigation skill assessment predominantly relies on self‐reports, with varying accounts regarding their validity. The current study aimed to determine whether performance on an objective visual scene memory recognition ability task could serve as a valid predictor of wayfinding navigation performance. A standardized sense of direction scale was used to compare the predictiveness of self‐report with the visual recognition test for objective navigation performance. Results from multiple regression analyses indicated that better performance on the visual, but not the verbal memory task significantly predicted wayfinding ability. Visual memory performance was also a better predictor of navigation performance than participants' self‐reported sense of direction. This study therefore suggests that the assessment of visual scene memory is a promising and ecologically valid way to predict everyday practical navigation ability—in addition to or instead of via the use of self‐reports.

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Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

Cited by 347 publications

References 146 publications

Spatial navigation ability predicts progression of dementia symptomatology

Spatial navigation ability predicts progression of dementia symptomatology

A unified brain system of orientation and its disruption in Alzheimer’s disease

Using visual scene memory accuracy as a predictor of spatial navigation performance

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