Spatial microenvironments tune immune response dynamics in theDrosophilalarval fat body
Brandon H. Schlomann,
Ting-Wei Pai,
Jazmin Sandhu
et al.
Abstract:Immune responses in tissues display intricate patterns of gene expression that vary across space and time. While such patterns have been increasingly linked to disease outcomes, the mechanisms that generate them and the logic behind them remain poorly understood. As a tractable model of spatial immune responses, we investigated heterogeneous expression of antimicrobial peptides in the larval fly fat body, an organ functionally analogous to the liver. To capture the dynamics of immune response across the full t… Show more
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