Spatial memory retention is enhanced by acute and continuous estradiol replacement

Sandstrom, Noah J.; Williams, Christina L.

doi:10.1016/j.yhbeh.2003.09.010

Cited by 112 publications

(72 citation statements)

References 48 publications

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“…Finally, for both estrogen and BDNF, the effects that have been observed exhibit unique and characteristic response patterns, that are not shared by any other humoral agent. Thus, estrogen has striking effects that range from alterations in behavior [5][6][7][8][9][10][11][12][13], structure (spine morphology, density, and spine synapses; Table 2), and physiology (potentiation of glutamatergic inputs in area CA1; Table 2) including specific receptormediated actions, such as actions at the NMDA receptor (although not exclusively; [14]). BDNF is the one other molecule that has been shown to exert many, if not all, of these same specific effects (Table 2).…”

Section: Estrogen and Bdnf In Hippocampus A Rationalementioning

confidence: 99%

“…This has been shown for male rats after manipulations that increase estradiol, and the reverse, that learning is worse when estradiol levels are low, for example in aromatase-knockout mice [42]. This has also been studied in female rats after ovariectomy and estradiol replacement, although it is difficult to compare some of these studies because doses of estradiol vary, as well as other potential factors such as age, time after ovariectomy, and housing [5][6][7][8][9][11][12][13]43]. The variability occurs not only in whether behavior is enhanced, but also the type of task.…”

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

“…The variability occurs not only in whether behavior is enhanced, but also the type of task. Thus, many studies of spatial learning (a classic hippocampal-dependent behavior) show an improvement after estradiol administration, but other types of memory can sometimes also improve, suggesting not only hippocampal effects but also non-hippocampal effects [5][6][7][8][9][11][12][13]43]. Learning appears to be enhanced on the morning of proestrus relative to other cycle stages or relative to ovariectomy [44].…”

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

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Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Scharfman

MacLusky

2006

Frontiers in Neuroendocrinology

264

202

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In the CNS, there are widespread and diverse interactions between growth factors and estrogen. Here we examine the interactions of estrogen and brain-derived neurotrophic factor (BDNF), two molecules that have historically been studied separately, despite the fact that they seem to share common targets, effects, and mechanisms of action. The demonstration of an estrogen-sensitive response element on the BDNF gene provided an impetus to explore a direct relationship between estrogen and BDNF, and predicted that the effects of estrogen, at least in part, might be due to the induction of BDNF. This hypothesis is discussed with respect to the hippocampus, where substantial evidence has accumulated in favor of it, but alternate hypotheses are also raised. It is suggested that some of the interactions between estrogen and BDNF, as well as the controversies and implications associated with their respective actions, may be best appreciated in light of the ability of BDNF to induce neuropeptide Y (NPY) synthesis in hippocampal neurons. Taken together, this tri-molecular cascade, estrogen-BDNF-NPY, may be important in understanding the hormonal regulation of hippocampal function. It may also be relevant to other regions of the CNS where estrogen is known to exert profound effects, such as amygdala and hypothalamus; and may provide greater insight into neurological disorders and psychiatric illness, including Alzheimer's disease, depression and epilepsy.

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Section: Estrogen and Bdnf In Hippocampus A Rationalementioning

confidence: 99%

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

Section: Comparison Of Estrogen and Bdnf Actions In Hippocampus-mentioning

confidence: 99%

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Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Scharfman

MacLusky

2006

Frontiers in Neuroendocrinology

264

202

View full text Add to dashboard Cite

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“…Behavioral testing in humans [12] and on spatial memory [13] or delayed matchingto-place [14] in rats. In the Cache County, women with hormone use at any age exhibit slower rates of cognitive decline, particularly the women aged 85 years or older [15] .…”

Section: Discussionmentioning

confidence: 99%

Effects of synaptic plasticity regulated by 17β-estradiol on learning and memory in rats with Alzheimer’s disease

et al. 2010

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Objective To investigate whether estrogen modulates learning and memory and long-term potentiation (LTP) in the hippocampus of rats with Alzheimer's disease (AD). Methods The rats were divided into ovariectomy (OVX) and estrogen replacement therapy (ERT) groups. Rats in the ERT group received OVX, followed by ERT, while rats in the OVX group received only OVX. The rat model of AD was established by injection of 1 μL (10 μg/μL) amyloid-beta peptide 1-40(Aβ 1-40 ) into the hippocampus. The learning and memory ability and LTP were determined by Morris water maze and electrophysiological method, respectively. Results The escape latency in Morris water maze significantly decreased in ERT group compared with that in OVX group (P < 0.05). Besides, rats in ERT group exhibited a significant enhancement of the magnitude of LTP at 30 min after high-frequency stimulation (HFS), compared with that in OVX group (P < 0.01). Conclusion ERT can attenuate the cognitive deficits in the rat model of AD, and estrogen can regulate LTP and synaptic remodeling in AD rats.

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“…Estrogen is intimately involved in the development and regulation of a variety of tissues, including the brain where it functions as a potent neuroprotective agent (Tang, 1996;Slooter, 1999) and a positive influencer of mood and cognition in both humans and rodents (Duff, 2000;Ahokas, 2001;Estrada-Camarena, 2003;Sandstrom, 2004;Almeida, 2005). Specifically, estrogen replacement in ovariectomized female rats significantly improves spatial memory retention as tested by a delayed matching-to-place water maze task (Sandstrom, 2004), and examination of the ERα knock-out mouse model (ERαKO) demonstrated that ERα is required for learning hippocampal-dependent inhibitory avoidance tasks (Fugger, 2000).…”

Section: Introductionmentioning

confidence: 99%

Modulation of αCaMKII signaling by rapid ERα action

et al. 2008

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The estrogen receptor (ER) subtypes, ERα and ERβ, modulate numerous signaling cascades in the brain to result in a variety of cell fates including neuronal differentiation. We report here that 17β-estradiol (E2) rapidly stimulates the autophosphorylation of α-Ca 2+ /calmodulin-dependent kinase II (αCaMKII) in immortalized NLT GnRH neurons, primary hippocampal neurons, and Cos7 cells cotransfected with ERα and αCaMKII. The E2-induced αCaMKII autophosphorylation is ERα-and Ca 2+ /calmodulin (CaM)-dependent. Interestingly, the hormone-dependent association of ERα with αCaMKII attenuates the positive effect of E2 on αCaMKII autophosphorylation, suggesting that ERα plays a complex role in modulating αCaMKII activity and may function to fine-tune αCaMKII-triggered signaling events. However, it appears as though the activating signal of E2 dominates the negative effect of ER since there is a clear, positive downstream response to E2-activated αCaMKII; pharmacological inhibitors and RNAi technology show that targets of ERα-mediated αCaMKII signaling include extracellular signal-regulated kinase 1/2 (ERK1/2), cAMP response elementbinding protein (CREB), and microtubule associated protein 2 (MAP2). These findings suggest a novel model for the modulation of αCaMKII signaling by ERα, which provides a molecular link as to how E2 might influence brain function.

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Spatial memory retention is enhanced by acute and continuous estradiol replacement

Cited by 112 publications

References 48 publications

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: Complexity of steroid hormone-growth factor interactions in the adult CNS

Effects of synaptic plasticity regulated by 17β-estradiol on learning and memory in rats with Alzheimer’s disease

Modulation of αCaMKII signaling by rapid ERα action

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