Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat

Gasbarri, Antonella

doi:10.1016/s0306-4522(96)00202-3

Cited by 46 publications

(51 citation statements)

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“…In this context, we concluded that D1R plays an important role in detecting spatial novelty encoded by spatial representations of hippocampal place cells, a prerequisite for spatial learning. The present work together with other recent studies (Gasbarri et al, 1996;Matthies et al, 1997;Otmakhova and Lisman, 1996;El-Ghundi et al, 1999;Swanson-Park et al, 1999;Wilkerson and Levin, 1999;Tran et al, 2002Tran et al, , 2005Li et al, 2003;Kentros et al, 2004;Gill and Mizumori, 2006;Stuchlik and Vales, 2006) should help significantly in revealing the mechanisms underlying the involvement of dopamine in learning and memory, from the molecular, to the neuronal, to the behavioral level.…”

Section: Discussionmentioning

confidence: 56%

“…Lesions or manipulations of the HF in rodents cause spatial learning deficits (Gasbarri et al, 1996;Whishaw et al, 1997;Wilkerson and Levin, 1999), and recordings of hippocampal neurons in rodents have revealed that they fire in a location-specific manner (O' Keefe and Dostrovsky, 1971;Wilson and McNaughton, 1993;O'Keefe and Burgess, 1996) in association with external and internal cues (Muller and Kubie, 1987;Wiener et al, 1989;Gothard et al, 1996;Hetherington and Shapiro, 1997;Shapiro et al, 1997;Knierim et al, 1998;Zinyuk et al, 2000;Lever et al, 2002;Leutgeb et al, 2005a,b) or contextual information (Gill and Mizumori, 2006), indicating a role in spatial memory (Wilson and McNaughton, 1993;Leutgeb et al, 2005). In addition, the HF appears to provide a neural representation of physical space, although broader functions have also been suggested (Maguire et al, 1998;Eichenbaum et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Tran¹,

Uwano²,

Kimura³

et al. 2008

J. Neurosci.

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The human hippocampus is critical for learning and memory. In rodents, hippocampal pyramidal neurons fire in a location-specific manner, forming relational representations of environmental cues. The importance of glutamatergic systems in learning and in hippocampal neural synaptic plasticity has been shown. However, the role of dopaminergic systems in the response of hippocampal neural plasticity to novel and familiar spatial stimuli remains unclear. To clarify this important issue, we recorded hippocampal neurons from dopamine D 1 receptor knock-out (D1R-KO) mice and their wild-type (WT) littermates under the manipulation of distinct spatial cues in a familiar and a novel environment. Here we report that in WT mice, the majority of place cells quickly responded to the manipulations of distal and proximal cues in both familiar and novel environments. In contrast, the influence of distal cues on spatial firing in D1R-KO mice was abolished. In the D1R-KO mice, the influence of proximal cues was facilitated in a familiar environment, and in a novel environment most of the place cells were less likely to respond to changes of spatial cues. Our results demonstrate that hippocampal neurons in mice can rapidly and flexibly encode information about space from both distal and proximal cues to cipher a novel environment. This ability is necessary for many types of learning, and lacking D1R can radically alter this learning-related neural activity. We propose that D1R is crucially implicated in encoding spatial information in novel environments, and influences the plasticity of hippocampal representations, which is important in spatial learning and memory.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Tran¹,

Uwano²,

Kimura³

et al. 2008

J. Neurosci.

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“…Since dopaminergic drugs were applied systemically, these experiments do not bear on the site of action. However, work with more selective depletion of dopamine in the hippocampus (Gasbarri et al, 1996a(Gasbarri et al, ,1996b showed impairment of spatial memory in rats, confirming the importance of the intrahippocampal dopaminergic system.…”

Section: Dopamine In the Hippocampus And Learningmentioning

confidence: 84%

Storage, recall, and novelty detection of sequences by the hippocampus: Elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine

2001

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ABSTRACT:In order to understand how the molecular or cellular defects that underlie a disease of the nervous system lead to the observable symptoms, it is necessary to develop a large-scale neural model. Such a model must specify how specific molecular processes contribute to neuronal function, how neurons contribute to network function, and how networks interact to produce behavior. This is a challenging undertaking, but some limited progress has been made in understanding the memory functions of the hippocampus with this degree of detail. There is increasing evidence that the hippocampus has a special role in the learning of sequences and the linkage of specific memories to context. In the first part of this paper, we review a model (the SOCRATIC model) that describes how the dentate and CA3 hippocampal regions could store and recall memory sequences in context. A major line of evidence for sequence recall is the "phase precession" of hippocampal place cells. In the second part of the paper, we review the evidence for theta-gamma phase coding. According to a framework that incorporates this form of coding, the phase precession is interpreted as cued recall of a discrete sequence of items from long-term memory. The third part of the paper deals with the issue of how the hippocampus could learn memory sequences. We show that if multiple items can be active within a theta cycle through the action of a short-term "buffer," NMDA-dependent plasticity can lead to the learning of sequences presented at realistic item separation intervals. The evidence for such a buffer function is reviewed. An important underlying issue is whether the hippocampal circuitry is configured differently for learning and recall. We argue that there are indeed separate states for learning and recall, but that both involve theta oscillations, albeit in possibly different forms. This raises the question of how neuromodulatory input might switch the hippocampus between learning and recall states and more generally how different neuromodulatory inputs reconfigure the hippocampus for different functions. In the fifth part of this paper we review our studies of dopamine and dopamine/NMDA interactions in the control of synaptic function. Our results show that dopamine dramatically reduces the direct cortical input to CA1 (the perforant path input), while having little effect on the input from CA3. In order to interpret the functional consequences of this pathway-specific modulation, it is necessary to understand the function of CA1 and the role of dopaminergic input from the ventral tegmental area (VTA). In the sixth part of this paper we consider several possibilities and address the issue of how dopamine hyperfunction or NMDA hypofunction, abnormalities that may underlie schizophrenia, might lead to the symptoms of the disease. Relevant to this issue is the demonstrated role of the hippocampus in novelty detection, a function that is likely to depend on sequence recall by the hippocampus. Novelty signals are generated when reality does not match ...

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“…Dopamine can promote long-term potentiation, a widely accepted model of hippocampus-dependent memory (Otmakhova and Lisman, 1996;Li et al, 2003), and improve hippocampusdependent learning in animals (Gasbarri et al, 1996;Bach et al, 1999;Schröder et al, 2003). In humans, pathological alterations in the dopaminergic system are often accompanied by memory deficits (van Oostrom et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

The Dopaminergic Midbrain Participates in Human Episodic Memory Formation: Evidence from Genetic Imaging

et al. 2006

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Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in dopamine clearance pathways affect encoding-related brain activity (functional magnetic resonance imaging) in an episodic memory task. In 51 young, healthy adults, successful episodic encoding was associated with activation of the substantia nigra. This midbrain activation was modulated by a functional variable number of tandem repeat (VNTR) polymorphism in the dopamine transporter (DAT1) gene. Despite no differences in memory performance between genotype groups, carriers of the (low expressing) 9-repeat allele of the DAT1 VNTR showed relatively higher midbrain activation when compared with subjects homozygous for the 10-repeat allele, who express DAT1 at higher levels. The catechol-O-methyl transferase (COMT) Val108/158Met polymorphism, which is known to modulate enzyme activity, affected encoding-related activity in the right prefrontal cortex (PFC) and in occipital brain regions but not in the midbrain. Moreover, subjects homozygous for the (low activity) Met allele showed stronger functional coupling between the PFC and the hippocampus during encoding. Our finding that genetic variations in the dopamine clearance pathways affect encoding-related activation patterns in midbrain and PFC provides strong support for a role of dopaminergic neuromodulation in human episodic memory formation. It also supports the hypothesis of anatomically and functionally distinct roles for DAT1 and COMT in dopamine metabolism, with DAT1 modulating rapid, phasic midbrain activity and COMT being particularly involved in prefrontal dopamine clearance.

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Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat

Cited by 46 publications

References 0 publications

Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Storage, recall, and novelty detection of sequences by the hippocampus: Elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine

The Dopaminergic Midbrain Participates in Human Episodic Memory Formation: Evidence from Genetic Imaging

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Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat

Cited by 46 publications

References 0 publications

Dopamine D1Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Dopamine D1Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Storage, recall, and novelty detection of sequences by the hippocampus: Elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine

The Dopaminergic Midbrain Participates in Human Episodic Memory Formation: Evidence from Genetic Imaging

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Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty

Dopamine D₁Receptor Modulates Hippocampal Representation Plasticity to Spatial Novelty