Spatial memory extinction differentially affects dorsal and ventral hippocampal metabolic activity and associated functional brain networks

Méndez-Couz, Marta; González-Pardo, Héctor; Vallejo, Guillermo; Árias, Jorge L.; Conejo, Nélida M.

doi:10.1002/hipo.22602

Cited by 14 publications

(9 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Renewal, shortly after extinction learning and in the absence of a prolonged consolidation period, has also been demonstrated in pigeons (Packheiser et al, 2019). These results agree with those obtained for extinction learning of different kinds of reference memory tasks (Méndez-Couz et al, 2014, 2016) and concur with results in human studies, where during extinction in a novel context, participants who showed a renewal effect, had previously shown quicker extinction learning and increased hippocampus activation (Lissek et al, 2013; Chang et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

“…Recent studies indicate that the hippocampus functionally differentiates between temporal, spatial and non-spatial experience, by means of robust proximodistal segregation of encoding of this information in CA1 and CA3 subfields, as well as the upper and lower blades of the dentate gyrus (DG; Beer et al, 2014, 2018; Hoang et al, 2018). Although the DG seems to provide an instructive signal that supports hippocampal encoding of memories, its role during extinction and retrieval is controversial and poorly understood (Méndez-Couz et al, 2015a, 2016; Bernier et al, 2017). All these findings suggest that the hippocampus may be able to differentiate between different components of an appetitive experience, including extinction learning and renewal.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Compartmentalization of the Contribution of Hippocampal Subfields to Context-Dependent Extinction Learning

Méndez-Couz

Becker

Manahan‐Vaughan

2019

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

During extinction learning (EL), an individual learns that a previously learned behavior no longer fulfills its original purpose, or is no longer relevant. Recent studies have contradicted earlier theories that EL comprises forgetting, or the inhibition of the previously learned behavior, and indicate that EL comprises new associative learning. This suggests that the hippocampus is involved in this process. Empirical evidence is lacking however. Here, we used fluorescence in situ hybridization of somatic immediate early gene (IEG) expression to scrutinize if the hippocampus processes EL. Rodents engaged in context-dependent EL and were also tested for renewal of (the original behavioral response to) a spatial appetitive task in a T-maze. Whereas distal and proximal CA1 subfields processed both EL and renewal, effects in the proximal CA1 were more robust consistent with a role of this subfield in processing context. The lower blade of the dentate gyrus (DG) and the proximal CA3 subfields were particularly involved in renewal. Responses in the distal and proximal CA3 subfields suggest that this hippocampal subregion may also contribute to the evaluation of the reward outcome. Taken together, our findings provide novel and direct evidence for the involvement of distinct hippocampal subfields in context-dependent EL and renewal.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Functional Compartmentalization of the Contribution of Hippocampal Subfields to Context-Dependent Extinction Learning

Méndez-Couz

Becker

Manahan‐Vaughan

2019

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Serial 30-μm-thick coronal sections were cut with a cryostat microtome (Microm HM-505E, Heidelberg, Germany) and mounted on microscope slides. Brain sections were processed for quantitative cytochrome c oxidase (CCO) histochemistry as previously described [34–36] based on the original method by Gonzalez-Lima and Cada (1994) [21]. Briefly, sections were incubated during 1 h at 37°C in a solution containing 50 mg diaminobenzidine, 15 mg cytochrome c (Sigma, St. Louis, MO, USA) and 4 g sucrose per 100 ml phosphate buffer (pH 7.4; 0.1 M).…”

Section: Methodsmentioning

confidence: 99%

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

González-Pardo¹,

Árias²,

Vallejo³

et al. 2019

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Early life stress is associated with long-term and pervasive adverse effects on neuroendocrine development, affecting normal cognitive and emotional development. Experimental manipulations like environmental enrichment (EE) may potentially reverse the effects of early life stress induced by maternal separation (MS) paradigm in rodents. However, the functional brain networks involved in the effects of EE after prolonged exposure to MS have not yet been investigated. In order to evaluate possible changes in brain functional connectivity induced by EE after MS, quantitative cytochrome c oxidase (CCO) histochemistry was applied to determine regional brain oxidative metabolism in adult male rats. Unexpectedly, results show that prolonged MS during the entire weaning period did not cause any detrimental effects on spatial learning and memory, including depressive-like behavior evaluated in the forced-swim test, and decreased anxiety-like behavior. However, EE seemed to alter anxiety- and depression-like behaviors in both control and MS groups, but improved spatial memory in the latter groups. Analysis of brain CCO activity showed significantly lower metabolic capacity in most brain regions selected in EE groups probably associated with chronic stress, but no effects of MS on brain metabolic capacity. In addition, principal component analysis of CCO activity revealed increased large-scale functional brain connectivity comprising at least three main networks affected by EE in both MS and control groups. Moreover, EE induced a pattern of functional brain connectivity associated with stress and anxiety-like behavior as compared with non-enriched groups. In conclusion, EE had differential effects on cognition and emotional behavior irrespective of exposure to MS. In view of the remarkable effects of EE on brain function and behavior, implementation of rodent housing conditions should be optimized by evaluating the balance between scientific validity and animal welfare.

show abstract

“…Some findings suggest that the hippocampus, cortex, and thalamus are significant areas of the brain for memory [93][94][95][96][97][98], while other research suggests the role of the hippocampus in working memory is controversial [99,100], or that the hippocampus is involved in the creation of the memory space, spatial maps, and navigation [97]. We suggest that the 3D default space is pre-existing and is represented by all the cells in the body.…”

Section: Memory Spacementioning

confidence: 75%

Meditation Experiences, Self, and Boundaries of Consciousness

Jerath¹,

Cearley²,

Barnes³

et al. 2016

IJCAM

View full text Add to dashboard Cite

Our experiences with the external world are possible mainly through vision, hearing, taste, touch, and smell providing us a sense of reality. How the brain is able to seamlessly integrate stimuli from our external and internal world into our sense of reality has yet to be adequately explained in the literature. We have previously proposed a three-dimensional unified model of consciousness that partly explains the dynamic mechanism. Here we further expand our model and include illustrations to provide a better conception of the ill-defined space within the self, providing insight into a unified mind-body concept. In this article, we propose that our senses "super-impose" on an existing dynamic space within us after a slight, imperceptible delay. The existing space includes the entire intrapersonal space and can also be called the "the body's internal 3D default space". We provide examples from meditation experiences to help explain how the sense of 'self ' can be experienced through meditation practice associated with underlying physiological processes that take place through cardio-respiratory synchronization and coherence that is developed among areas of the brain. Meditation practice can help keep the body in a parasympathetic dominant state during meditation, allowing an experience of inner 'self '. Understanding this physical and functional space could help unlock the mysteries of the function of memory and cognition, allowing clinicians to better recognize and treat disorders of the mind by recommending proven techniques to reduce stress as an adjunct to medication treatment. allows us to experience an internal representation of the external environment. In the following sections we discuss the purpose of brain oscillations in consciousness, and further explain the formation of our previously proposed 3D default space theory, see [11]. Brain oscillations and the 3d default spaceWe consider brain oscillations dynamic because sensory and cortical information is organized around the thalamus which allows us to experience the external world. Alpha, gamma, retinogeniculo-cortical, and corticothalamic oscillations are essential in forming the 3D default space because they allow constant and continuous communication between the brain and the body-without them, we do not think that consciousness can emerge.Alpha oscillations vibrate at 8-14 Hz, strongly influencing brain activity [12,13] It is through these fast alpha and gamma oscillations that we suggest an 'internal' neural space is formed, providing an infrastructure for visual consciousness. Neuronal synchronization with the lateral geniculate nucleus (LGN) through oscillations at 60-120 Hz is indicated by oscillatory activity in the retina, LGN, and cortex [21,22], which allows the brain and retina to receive and process visual stimuli as one organ. These retinogeniculocortical oscillations assist in the formation of the dynamic template that reduces external space into our internal world space we call the 3D default space. These fast oscillations an...

show abstract

Spatial memory extinction differentially affects dorsal and ventral hippocampal metabolic activity and associated functional brain networks

Cited by 14 publications

References 69 publications

Functional Compartmentalization of the Contribution of Hippocampal Subfields to Context-Dependent Extinction Learning

Functional Compartmentalization of the Contribution of Hippocampal Subfields to Context-Dependent Extinction Learning

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

Meditation Experiences, Self, and Boundaries of Consciousness

Contact Info

Product

Resources

About