Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects
Lauren Adams,
Orhan Rasid,
Heather Hulme
et al.
Abstract:Inflammatory bowel disease (IBD) is a multifactorial disease and patients frequently experience extraintestinal manifestations affecting multiple sites. Causes of systemic inflammation remain poorly understood but molecules originating from the intestine likely play a role with microbial and host small molecules polarizing host immune cells towards a pro- or anti-inflammatory phenotype. Using the dextran sodium sulphate (DSS) mouse model, which mimics models the disrupted barrier function in IBD, microbial dys… Show more
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