Spatial learning and memory as a function of age in the dog.

Head, Elizabeth; Mehta, Rick; Hartley, Jason; Kameka, M.; Cummings, Brian J.; Cotman, Carl W.; Ruehl, William W.; Milgram, Norton W.

doi:10.1037//0735-7044.109.5.851

Cited by 43 publications

(4 citation statements)

References 49 publications

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“…Age-related cognitive impairments have been extensively studied. Notably, it is well-established that aged animals have worse learning and memory capabilities as compared to young ones [132][133][134][135]. In terms of synaptic plasticity, it is noted that LTP induced in aged animals has a diminished magnitude in the late phase compared to young animals, and that this reduction is correlated with memory impairments in the aged animal [135].…”

Section: (D) Ageingmentioning

confidence: 99%

Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease

Bin Ibrahim,

Wang,

Sajikumar

2024

Phil. Trans. R. Soc. B

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The synaptic tagging and capture (STC) hypothesis lays the framework on the synapse-specific mechanism of protein synthesis-dependent long-term plasticity upon synaptic induction. Activated synapses will display a transient tag that will capture plasticity-related products (PRPs). These two events, tag setting and PRP synthesis, can be teased apart and have been studied extensively—from their electrophysiological and pharmacological properties to the molecular events involved. Consequently, the hypothesis also permits interactions of synaptic populations that encode different memories within the same neuronal population—hence, it gives rise to the associativity of plasticity. In this review, the recent advances and progress since the experimental debut of the STC hypothesis will be shared. This includes the role of neuromodulation in PRP synthesis and tag integrity, behavioural correlates of the hypothesis and modelling in silico . STC, as a more sensitive assay for synaptic health, can also assess neuronal aberrations. We will also expound how synaptic plasticity and associativity are altered in ageing-related decline and pathological conditions such as juvenile stress, cancer, sleep deprivation and Alzheimer’s disease. This article is part of a discussion meeting issue ‘Long-term potentiation: 50 years on’.

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Section: (D) Ageingmentioning

confidence: 99%

Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease

Bin Ibrahim,

Wang,

Sajikumar

2024

Phil. Trans. R. Soc. B

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“…The spatial periodicity of grid cells is often correlated with theta wave oscillation (6 -12 Hz) 40,41 . To examine whether local field potential (LFP) in MEC alters during aging, we analyzed theta (6)(7)(8)(9)(10)(11)(12) and slow gamma (20 -30 Hz) power of 3 young mice from 187 sessions and 7 old mice from 446 sessions. Old mice exhibited a significant reduction in their theta power (young mice: 48.30 ± 2.34, old mice: 33.85 ± 1.52; Mann-Whitney U-test, P = 7.48 × 10 -15 , Figure S4A and S4B), and slow gamma power (young mice: 6.28 ± 0.78, old mice: 6.96 ± 0.49; Mann-Whitney U-test, P = 0.02, Figure S4A and S4B).…”

Section: Theta and Gamma Power Were Decreased In Old Micementioning

confidence: 99%

“…Cognitive decline, which includes pathological features such as spatial memory deficiency, is one of the biggest challenges faced by older people in aging societies 1,2 . Based on their discovery in most species, including humans 3,4 , nonhuman primates 5 , dogs 6 , rats 7 , and mice 8 , age-related cognitive deficiencies in spatial learning and memory are evolutionarily conserved. Therefore, it is important to conduct animal studies to understand the underlying mechanism of age-related cognitive decline in humans.…”

Section: Introductionmentioning

confidence: 99%

Cellular and Molecular Changes During Aging in MEC: Unveiling the Role of Bglap3 Neurons in Cognitive Aging

Cao,

Uzeen,

Cheng

et al. 2024

Preprint

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SummaryAging-correlated cognitive declines, including deficiencies in spatial orientation and memory, may reflect dysfunction in the hippocampus and medial entorhinal cortex (MEC). However, aging-related changes in MEC at the cellular and molecular levels remain unclear. In this study, we found fewer grid cells with reduced spatial stability in old mice. We compared gene expression profiles between young and old mice using 10x Genomics Visium technology. Among 1664 differentially expressed genes, we discovered Bglap3, a marker gene for subpopulation in MEC Layer III with decreased cell number with age. Silencing of Bglap3+ neurons in young mice impaired the spatial tuning of neurons in MEC and the spatial learning of a new platform location in water maze. These findings help us to understand the cellular and molecular changes in the MEC in healthy aging animals and the changes of Bglap3+ cells in old mice indicating a possible cause of aging-related MEC deficiency.

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“…Age-related cognitive impairment of the dogs parallels the cognitive symptomology of AD. The earliest deficits are most evident in performance on tasks involving working (short-term) memory and complex learning [ 7 ]. Affected dogs additionally develop deficits in discrimination learning as well as behavioral changes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease

Kutzsche¹,

Schemmert²,

Bujnicki³

et al. 2023

Heliyon

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Spatial learning and memory as a function of age in the dog.

Cited by 43 publications

References 49 publications

Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease

Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease

Cellular and Molecular Changes During Aging in MEC: Unveiling the Role of Bglap3 Neurons in Cognitive Aging

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease

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