Spatial interaction between breast cancer and environmental pollution in the Monterrey Metropolitan Area

Gasca-Sanchez, Francisco; Santuario‐Facio, Sandra K.; Ortı́z-López, Rocio; Rojas-Martínez, Augusto; Mejia-Velazquez, Gerardo M.; Garza-Perez, Erick Meinardo; Hernández-Hernández, José Ascención; López-Sánchez, R.; Cardona‐Huerta, Servando; Santos-Guzmán, Jesús

doi:10.1016/j.heliyon.2021.e07915

Cited by 7 publications

(6 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among cancer types, breast cancer is the most common cancer found in women and causes their deaths [ 2 ]. Many studies have revealed that breast cancer is caused by environmental factors, such as obesity [ 3 ], heavy smoking [ 4 ], and genetic factors such as breast cancer gene ( BRCA) 1 , BRCA2 , phosphatase and tensin homolog ( PTEN ), tumor protein P53 ( TP53 ), cadherin 1 ( CDH1 ), and serine/threonine kinase 11 ( STK11 ) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

GWAK

2024

View full text Add to dashboard Cite

Genetic information is transcribed from genomic DNA to mRNA, which is then translated into three-dimensional proteins. mRNAs can undergo various post-transcriptional modifications, including RNA editing that alters mRNA sequences, ultimately affecting protein function. In this study, RNA editing was identified at the 499th base (c.499) of human vaccinia-related kinase 2 (VRK2). This RNA editing changes the amino acid in the catalytic domain of VRK2 from isoleucine (with adenine base) to valine (with guanine base). Isoleucine-containing VRK2 has higher kinase activity than the valine-containing VRK2, which leads to an increase in tumor cell proliferation. Earlier we reported that VRK2 directly interacts with dystrobrevin-binding protein (dysbindin) and results in reducing its stability. Herein, we demonstrate that isoleucine-containing VRK2 decreases the level of dysbindin than valine-containing VRK2. Dysbindin interacts with cyclin D and thereby regulates its expression and function. The reduction in the level of dysbindin by isoleucine-containing VRK2 further enhances the cyclin D expression, resulting in increased tumor growth and reduction in survival rates. It has also been observed that in patient samples, VRK2 level was elevated in breast cancer tissue compared to normal breast tissue. Additionally, the isoleucine form of VRK2 exhibited a greater increase in breast cancer tissue. Therefore, it is concluded that VRK2, especially dependent on the 167th variant amino acid, can be one of the indexes of tumor progression and proliferation.

show abstract

Section: Introductionmentioning

confidence: 99%

Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

GWAK

2024

View full text Add to dashboard Cite

show abstract

“…Sin embargo, los estudios poblacionales que han evaluado la asociación entre la exposición a la contaminación del aire y el cáncer de mama no han sido consistentes [44]. Si bien se han encontrado asociaciones fuertes con óxidos de nitrógeno (NO x ) y dióxido de nitrógeno (NO 2 ) [11,14], especialmente con cáncer de mama ER(+)/PR(+) [45], en el caso del PM, los hallazgos de estudios epidemiológicos recientes son muy variables, encontrándose relaciones fuertes [13], moderadas o débiles; incluso algunos estudios han sugerido que la exposición a PM puede aumentar la mortalidad pero no la morbilidad por esta patología [21].…”

Section: Discussionunclassified

“…Algunos estudios epidemiológicos han reportado hallazgos estadísticamente significativos, que señalan una relación entre la exposición a contaminantes del aire y la incidencia de cáncer de mama [8,[11][12][13]. En la mezcla de contaminantes en el aire confluyen compuestos como hidrocarburos aromáticos policíclicos (HAP) y metales que pueden actuar como cancerígenos o disruptores endocrinos [14].…”

Section: Introductionunclassified

“…Uno de los compuestos que se ha relacionado con el cáncer de mama, tanto en el ámbito laboral como ambiental, es el material particulado (PM, por sus siglas en inglés, Particulate Matter) [13], el cual hace parte de los contaminantes del aire clasificados como cancerígenos para los seres humanos, según la Agencia Internacional para la Investigación en Cáncer [15]. El PM es una mezcla heterogénea de partículas y gases que provienen principalmente de diferentes fuentes como la industria, el transporte y la generación de energía [9].…”

Section: Introductionunclassified

See 1 more Smart Citation

Exposición a material particulado y su relación con el cáncer de mama. Mecanismos fisiopatológicos

Mera-Mamián¹,

Villarreal‐Garza

Segura-Cardona³

et al. 2023

Med. Lab.

View full text Add to dashboard Cite

Resumen. Introducción. El cáncer de mama es el tipo de cáncer que genera más muertes en mujeres en el mundo. Aunque se reconoce el aporte de factores genéticos, hormonales y de estilos de vida como sus principales causas, las hipótesis que señalan que la contaminación del ambiente juega un papel importante en su desarrollo, han tomado mucha fuerza en los últimos años. Estas hipótesis surgen debido a que el aumento en la incidencia del cáncer de mama coincide con procesos de industrialización, además de mayor presencia en regiones urbanas y con altos niveles de contaminación. El objetivo de este artículo fue consolidar información sobre los mecanismos fisiopatológicos que puedan explicar la relación entre cáncer de mama y la contaminación por material particulado. Metodología. Se realizó una búsqueda de literatura en PubMed, Google Académico y Epistemonikos para documentos publicados sobre el tema desde enero de 2016 hasta el 3 de agosto de 2022. Resultados. Se encontró que algunos de los mecanismos que podrían explicar dicha relación incluyen: alteraciones endocrinas que favorecen cambios hormonales, induciendo el crecimiento mamario; cambios en las características histológicas del tejido normal, como involución reducida de unidades lobulares ductales terminales; formación de aductos de hidrocarburos aromáticospolicíclicos-ácido desoxirribonucleico (HAP-ADN), con mutación específica del gen TP53; activación de la proliferación en la línea celular MCF-7; y, alteraciones en la metilación del ADN. Conclusión. Si bien órganos distales como la mama no son la primera entrada de los contaminantes ambientales al cuerpo, estos sí pueden verse afectados tras la exposición a largo plazo, a través de diferentes mecanismos de disrupción endocrina y daño al ADN principalmente.

show abstract

“…PM2.5, NO2, and traffic-related emissions may act as mammary carcinogens [ 15 , 82 ]. A study in Mexico found significant geospatial clustering of BC cases near pollution sources including refineries and industrial facilities [ 83 ]. However, the associations with PM are complex; specific components like nickel and vanadium, rather than overall PM levels, may drive the increased risk [ 73 – 75 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the geospatial epidemiology of breast cancer in Iran: identifying significant risk factors and spatial patterns for evidence-based prevention strategies

Soleimani,

Ayyoubzadeh,

Jalilvand

et al. 2023

BMC Cancer

View full text Add to dashboard Cite

Background Breast Cancer (BC) is a formidable global health challenge, and Iran is no exception, with BC accounting for a significant proportion of women’s malignancies. To gain deeper insights into the epidemiological characteristics of BC in Iran, this study employs advanced geospatial techniques and feature selection methods to identify significant risk factors and spatial patterns associated with BC incidence. Methods Using rigorous statistical methods, geospatial data from Iran, including cancer-related, sociodemographic, healthcare infrastructure, environmental, and air quality data at the provincial level, were meticulously analyzed. Age-standardized incidence rates (ASR) are calculated, and different regression models are used to identify significant variables associated with BC incidence. Spatial analysis techniques, including global and local Moran's index, geographically weighted regression, and Emerging hotspot analysis, were utilized to examine geospatial patterns, identify clustering and hotspots, and assess spatiotemporal distribution of BC incidence. Results The findings reveal that BC predominantly affects women (98.03%), with higher incidence rates among those aged 50 to 79. Isfahan (ASR = 26.1) and Yazd (ASR = 25.7) exhibit the highest rates. Significant predictors of BC incidence, such as marriage, tertiary education attainment rate, physician-to-population ratio, and PM2.5 air pollution, are identified through regression models. Conclusion The study's results provide valuable information for the development of evidence-based prevention strategies to reduce the burden of BC in Iran. The findings underscore the importance of early detection, health education campaigns, and targeted interventions in high-risk clusters and adjacent regions. The geospatial insights generated by this study have implications for policy-makers, researchers, and public health practitioners, facilitating the formulation of effective BC prevention strategies tailored to the unique epidemiological patterns in Iran.

show abstract

Spatial interaction between breast cancer and environmental pollution in the Monterrey Metropolitan Area

Cited by 7 publications

References 67 publications

Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity

Exposición a material particulado y su relación con el cáncer de mama. Mecanismos fisiopatológicos

Exploring the geospatial epidemiology of breast cancer in Iran: identifying significant risk factors and spatial patterns for evidence-based prevention strategies

Contact Info

Product

Resources

About