Spatial firing properties of lateral septal neurons

Takamura, Yusaku; Tamura, Ryoi; Zhou, Tian Lu; Kobayashi, Takuma; Tran, Anh T.; Eifuku, Satoshi; Ono, Taketoshi

doi:10.1002/hipo.20196

Cited by 27 publications

(48 citation statements)

References 62 publications

(79 reference statements)

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“…These results were consistent with previous findings that showed LS neurons are involved in both context and reward associations (Shoji et al, 1997; Takamura et al, 2006; Luo et al, 2011). Finally, we used a bilateral disconnection method with orexin antisense unilaterally in LH and inactivation of contralateral LS with B-M to confirm that an influence of LS afferents on LH orexin neurons is necessary for cocaine preference.…”

Section: Discussionsupporting

confidence: 94%

“…Both rostral and caudal LS have massive connections with the dorsal hippocampus (Risold and Swanson, 1996, 1997a) and have been implicated in spatial and contextual information processing (Rawlins and Olton, 1982; Fraser et al, 1991; Takamura et al, 2006; Calandreau et al, 2007). In addition, LS has strong connections with brain regions associated with reward and motivation (hypothalamus, amygdala, and VTA) (Risold and Swanson, 1997a), and is important in many behaviors associated with motivation (Olds and Milner, 1954; Prado-Alcala et al, 1984; Cazala et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that LH, and specifically LH orexin neurons, receive inputs from LS (Risold and Swanson, 1997a; Yoshida et al, 2006). Furthermore, LS and LH orexin neurons are responsive both to drugs of abuse (Shoji et al, 1997; Shoji et al, 1998; Harris et al, 2007; Pasumarthi and Fadel, 2008) and to contextual information associated with reward (Harris et al, 2005; Takamura et al, 2006). Based on these previous findings, we sought to determine if the LS to LH orexin circuit is important in cocaine CPP.…”

Section: Introductionmentioning

confidence: 99%

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A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

2012

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Orexins (also called hypocretins) have been shown to be importantly involved in reward and addiction, but little is known about the circuitry that regulates orexin neuronal activity during drug-seeking behaviors. Here, we examined inputs to the lateral hypothalamic (LH) orexin cell field from the lateral septum (LS) using tract-tracing and Fos immunohistochemistry after cocaine (10mg/kg) conditioned place preference (CPP) in Sprague Dawley rats. We found that neurons in rostral LS (LSr) that project to LH are Fos-activated in proportion to cocaine CPP, and that inhibition of LSr neurons with local baclofen and muscimol microinjection (0.3/0.03 nmol) blocks expression of Fos in LH orexin cells and cocaine preference. In addition, using local inactivation in LS and orexin antisense Morpholinos in LH, we found that LSr influences on LH orexin neurons are critical for the expression of cocaine preference. These results indicate that LSr activates LH orexin neurons during cocaine place preference, and that this circuit is essential for expression of cocaine place preference.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

2012

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“…This supposition is supported by the finding that (i) the lateral septum exhibits spatially tuned activity (Leutgeb & Mizumori, ), and (ii) the hippocampus is the only anatomical region encoding spatial representation that projects to the lateral septum. Recordings from the rostral part of lateral septum showed that 15 from 28 neurons (Zhou et al ., ) and 81 of 193 (Takamura et al ., ) expressed place‐related activity. The spatial reorganisation of the lateral septal location coding is proposed to occur as a direct consequence of hippocampal reorganisation (Leutgeb & Mizumori, ).…”

Section: Descending Hippocampo‐septal Signal Propagationmentioning

confidence: 99%

Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration

Tsanov

2017

Eur J of Neuroscience

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Anatomical differences between the medial and lateral septum have associated these nuclei with dissimilar functional roles and behaviours. While the medial septum has been implicated, predominantly, in theta rhythm generation along the septo-hippocampal axis, the lateral septum has mainly been investigated in the context of septo-hypothalamic dialogue. Recent advances suggest that medial and lateral septum are more closely functionally related than previously appreciated. Here, we explore the hypothesis that the medial septum mediates ascending septo-hippocampal theta propagation, while the lateral septum processes a descending hippocampo-septal and septo-hypothalamic reinforcement signal that mediates navigation during motivated behaviour. The generation and propagation of theta rhythm are critical for the initiation of exploratory behaviour. Indeed, theta signal processing of medial and lateral septum nuclei may well be involved in the integration of spatial, rewarding and locomotor signals across different brain networks. We review here the structural features, anatomical connectivity and functional properties of the medial and lateral septum. We discuss the heterogeneous anatomy of the lateral septum, which is composed of diverse subregions with distinct ascending and descending projections, and we relate the physiological characteristics of septal nuclei to their functional relationships with the hippocampal formation, the hypothalamus and the brainstem reticular formation during motivated spatial navigation.

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“…These cells 465 are well-placed to combine theta oscillations and spatial inputs (Takamura et al, 2006), as 466 required for the phaser mechanism, and to participate in subcortical theta-rhythmic feedback 467 and regulatory circuits (Leranth et al, 1999;Luo et al, 2011;Sartor & Aston-Jones, 2012;Ruan 468 29 .…”

mentioning

confidence: 99%

Spatial Theta Cells in Competitive Burst Synchronization Networks: Reference Frames from Phase Codes

Monaco

Blair²,

Zhang

2017

Preprint

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1Spatial cells of the hippocampal formation are embedded in networks of theta cells. The septal 2 theta rhythm (6-10 Hz) organizes the spatial activity of place and grid cells in time, but it remains 3 unclear how spatial reference points organize the temporal activity of theta cells in space. We 4 study spatial theta cells in simulations and single-unit recordings from exploring rats to ask 5 whether temporal phase codes may anchor spatial representations to the outside world. We 6 theorize that an experience-independent mechanism for temporal coding may combine with 7 burst synchronization to continuously calibrate self-motion to allocentric reference frames.

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Spatial firing properties of lateral septal neurons

Cited by 27 publications

References 62 publications

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

A Septal-Hypothalamic Pathway Drives Orexin Neurons, Which Is Necessary for Conditioned Cocaine Preference

Differential and complementary roles of medial and lateral septum in the orchestration of limbic oscillations and signal integration

Spatial Theta Cells in Competitive Burst Synchronization Networks: Reference Frames from Phase Codes

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