Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless

Riggleman, Bob; Schedl, Paul; Wieschaus, Eric

doi:10.1016/0092-8674(90)90451-j

Cited by 364 publications

(256 citation statements)

References 38 publications

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“…Moreover, all three are expressed uniformly in the embryonic epidermis (Riggleman et al 1990;Siegfried et al 1990), as expected based on the ability of all such cells to respond to Wg (Noordermeer et al 1992). …”

Section: Molecular Identification Of Dshmentioning

confidence: 86%

“…Candidates for genes involved in wg signaling in the embryonic epidermis are the other segment polarity genes, especially those resulting in a mutant cuticle phenotype like that of wg. Based on similarity of phenotypes and time course of En decay, the matemal-effect segment polarity genes armadillo (arm) (Klingensmith et al 1989;Peifer et al 1991 ), dishevelled (dsh) and porcupine (Klingensmith and Perrimon 1991;van den Heuvel et al 1993a) may encode components of the wg pathway, arm, a catenin-like junction protein (Peifer et al 1992), is a target of wg signaling, in that wg directs post-transcriptional accumulation of Arm protein in cells including and flanking the wg stripe (Riggleman et al 1990). This effect of wg was evaluated in various segment polarity mutant backgrounds, and dsh appears to be an essential requirement.…”

mentioning

confidence: 99%

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The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

Klingensmith

Nusse²,

Perrimon³

1994

Genes Dev.

369

209

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Section: Molecular Identification Of Dshmentioning

confidence: 86%

mentioning

confidence: 99%

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

Klingensmith

Nusse²,

Perrimon³

1994

Genes Dev.

369

209

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“…Since the original observation that the level of Armadillo, the fly β-catenin homologue, is controlled by Wnt signaling [17], much work for the past 20 years has been focused on β-catenin, a multifunctional protein, with essential roles in cell adhesion and target gene regulation [18][19][20]. Antisense depletion of β-catenin in Xenopus embryos [21] and its genetic knockouts in mice [22,23] demonstrated a critical role for β-catenin in body axis specification and Wnt signaling.…”

Section: The Wnt/β-catenin Pathwaymentioning

confidence: 99%

Wnt signaling through T-cell factor phosphorylation

Sokol

2011

Cell Res

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Embryonic signaling pathways often lead to a switch from default repression to transcriptional activation of target genes. A major consequence of Wnt signaling is stabilization of β-catenin, which associates with T-cell factors (TCFs) and 'converts' them from repressors into transcriptional activators. The molecular mechanisms responsible for this conversion remain poorly understood. Several studies have reported on the regulation of TCF by phosphorylation, yet its physiological significance has been unclear: in some cases it appears to promote target gene activation, in others Wnt-dependent transcription is inhibited. This review focuses on recent progress in the understanding of contextdependent post-translational regulation of TCF function by Wnt signaling.

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“…The lacZ reporter gene constructs used are UAS-lacZ (Brand and Perrimon, 1993) and dpp-lacZ (Blackman et al, 1991). The primary antibodies used are, antihAPC (Hayashi et al, 1997), anti-Arm (Riggleman et al, 1990), anti-Dll (Vachon et al, 1992), anti-Dac (Mardon et al, 1994) andanti-Wg (Brook and. Anti-Arm and anti-Wg were obtained from the Development Studies Hybridoma Bank, University of Iowa, USA.…”

Section: Histologymentioning

confidence: 99%