Spatial distribution of hydrophobic compounds in polymer micelles as explored by anomalous small-angle X-ray scattering near Br K-edge

Nakanishi, Ryosuke; Kinoshita, Masaki; Sasaki, Shota; Akiba, Isamu

doi:10.1016/j.eurpolymj.2015.12.024

Cited by 3 publications

(1 citation statement)

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“…This result means that a part of BrPh filtrates to hydrated shell layer of PEG- b -PtBMA micelles. This result is consistent with the spatial distribution of a phenol derivative incorporated in spherical polymer micelles reported by Sanada et al [ 14 ] and some of our previous studies [ 13 , 17 ]. BrPh can form hydrogen bonds with both PtBMA and PEG.…”

Section: Resultssupporting

confidence: 94%

Elucidation of Spatial Distribution of Hydrophobic Aromatic Compounds Encapsulated in Polymer Micelles by Anomalous Small-Angle X-ray Scattering

et al. 2018

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Spatial distribution of bromobenzene (BrBz) and 4-bromophenol (BrPh) as hydrophobic aromatic compounds incorporated in polymer micelles with vesicular structure consisting of poly(ethylene glycol)-b-poly(tert-butyl methacrylate) (PEG-b-PtBMA) in aqueous solution is investigated by anomalous small-angle X-ray scattering (ASAXS) analyses near Br K edge. Small-angle X-ray scattering (SAXS) intensities from PEG-b-PtBMA micelles containing BrBz and BrPh were decreased as the energy of incident X-ray approached to Br K edge corresponding to the energy dependence of anomalous scattering factor of Br. The analysis for the energy dependence of SAXS profiles from the PEG-b-PtBMA micelles containing BrBz revealed that BrBz molecules were located in hydrophobic layer of PEG-b-PtBMA micelles. On the contrary, it was found by ASAXS that BrPh existed not only in the hydrophobic layer but also in the shell layer. Since ASAXS analysis successfully accomplished to visualize the spatial distribution of hydrophobic molecules in polymer micelles, it should be expected to be a powerful tool for characterization of drug delivery vehicles.

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Section: Resultssupporting

confidence: 94%