BackgroundEvidence suggests that the built environment can influence the intensity of physical activity. However, most of the studies do not consider the geographic context of this association. Studies assessing the spatial dependence of physical activity are limited by an aggregated geographic scale or self-reported physical activity. We aimed to assess individual spatial dependence of objectively measured moderate and vigorous physical activity (MVPA) and describe the characteristics of the built environment among spatial clusters of MVPA.MethodsCross-sectional data from the second follow-up of CoLaus|PsyCoLaus (2014-2017), a longitudinal population-based study of the Lausanne area (Switzerland), was used to objectively measure daily MVPA using accelerometers. We ran Local Moran’s I to assess the spatial dependence of MVPA. This method compares the behavior (MVPA) of participants to that of other individuals located in the same neighborhood. It classifies individuals into four categories: high MVPA clusters, low MVPA clusters, low MVPA outliers in high MVPA clusters, and high MVPA outliers in low MVPA clusters. Additionally, the characteristics of the built environment observed in the clusters based on raw MVPA and MVPA adjusted for socioeconomic and demographic factors were described.ResultsData from 1,889 participants (median age 63 years, 55% women) were used. The geographic distribution of MVPA and the characteristics of the built environment among clusters were similar for raw and adjusted MVPA. In the adjusted model, we found a low concentration of individuals within spatial clusters of high MVPA (median: 36.9 mins; 3% of the studied population) and low MVPA (median: 10.1 mins; 2% of the studied population). Yet, clear differences were found in both models between clusters regarding the built environment; High MVPA clusters were located in areas with a higher density of parks, recreational, public, and commercial & industrial areas, preferential pedestrian zones, population density, cycling pathways, public transport accessibility and interconnected streets than low MVPA clusters.ConclusionsAlthough with few individuals within clusters, MVPA clusters were identified. The built environment may influence spatial patterns of MVPA independently of socioeconomic and demographic factors. Interventions in the built environment should be considered to promote physically active behaviors in urban areas.