Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease

Abstract

Paneth cell metaplasia is a non-specific phenomenon in the proximal colon, but distal PCM, which occurs exclusively in affected mucosa, is a useful marker indicating IBD, even in the inactive phase. Regression analysis suggests that repair and regeneration may be the most potent stimuli causing PCM.

Evaluating the association between histological manifestations of cord colitis syndrome with GVHD

“…30 It is more frequently observed at the ascending colon and cecum than at distal sites of elderly individuals and in affected mucosa than in healthy mucosa in patients with inflammatory bowel diseases. 16 Nevertheless, our results indicate that the presence of chronic active colitis with granuloma and/or Paneth cell metaplasia is not a specific feature of CCS. Prospective studies of the larger numbers of patients including, particularly, CBT patients are required to evaluate the incidence of chronic active colitis with granuloma and/or Paneth cell metaplasia in CCS, GVHD and other infectious colitis.…”

“…16,18 Paneth cells regulate the composition of colonized microbes in the intestine and protect epithelial cells from bacterial invasion. 19,20 We recently demonstrated that Paneth cells are targeted by GVHD, resulting in a subsequent alteration in the intestinal flora.…”

Colonic lymphoid follicles and NOD2/CARD15 mutational status in Crohn's disease

“…Previous studies have demonstrated that the NOD2/CARD15 gene is mainly expressed in Paneth cells, constitutively present in jejunum and ileum but also in the colon, mostly as metaplastic cells 18 . In these cells mutation of the NOD2/CARD15 gene reduces the expression of α-defensins, confirming its role in innate immunity 19 .…”

Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in crohnʼs disease

“…In addition, we found significant upregulation of lysozyme in actively inflamed colonic epithelium in CD and UC, which is consistent with the characteristic finding of colonic Paneth cell metaplasia in IBD. 8 Despite the above, we must point out that the scope of this study is limited. Due to the complex and time-consuming laser microdissection process we waived the analysis of noninflamed colon tissue of CD patients.…”