Spatial correspondence between tactile projection patterns and the distribution of the antigenic Purkinje cell markers anti-zebrin I and anti-zebrin II in the cerebellar folium crus IIa of the rat

Hallem, J.S; Thompson, John H.; Gundappa-Sulur, G; Hawkes, Richard; Bjaalie, Jan G.; Bower, James M.

doi:10.1016/s0306-4522(99)00144-x

Cited by 77 publications

(69 citation statements)

References 38 publications

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“…However, the origin of the participating mossy fibers was not specified in that study. Congruence of peripherally triggered mossy fibers and climbing fibers has been shown by comparing the receptive fields of peripheral mossy and climbing fibers responses in a selected region of crus 2 (Brown and Bower, 2001) and by relating this to the zonal distribution of the zebrin pattern of Purkinje cells (Hallem et al, 1999). Cerebrally evoked somatosensory mossy fiber responses have been shown to be in register with the peripherally evoked patterning (Bower et al, 1981).…”

Section: Modular Organization Of Climbing and Mossy Fiber Connectionsmentioning

confidence: 96%

Organization of pontocerebellar projections to identified climbing fiber zones in the rat

Pijpers

Ruigrok

2006

J of Comparative Neurology

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The organization of pontocerebellar projections to the paravermis and hemisphere of the posterior cerebellum of the rat was studied in relation to the organization of climbing fibers. Small injections of cholera toxin subunit B were placed in the cerebellar cortex at locations predetermined by evoked climbing fiber potentials from selected body parts or based on coordinates. The injection site was characterized with respect to the zebrin pattern and by the distribution of retrogradely labeled neurons in the inferior olive. The following zones were studied: hindlimb-related zones C1 and C2 of lobule VIII; forelimb-related zones C1, C2, and D0/D1 of the paramedian lobule; and face-related zones A2 of the paramedian lobule and C2 and D0 of crus 2B. The results show that the distribution of pontine neurons is closely related to the climbing fiber somatotopy. Injections centered on face-related zones result in distribution of pontine neurons within the pontine core region. Forelimb regions surround this core, whereas hindlimb regions are mostly supplied by caudal pontine regions and by a single patch of more rostrally located neurons. This distribution fits well with published data on the somatotopy of the corticopontine projection from the rat primary somatosensory cortex. However, apart from differences in the participation of ipsilaterally projecting cells, the distribution of pontine neurons does not change significantly when the injection covers different zones of the same lobule such as C1 and C2 of lobule VIII; C1, C2, and D0/D1 of the paramedian lobule; A2 of the paramedian lobule; and C2 and D0 of crus 2B.

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Section: Modular Organization Of Climbing and Mossy Fiber Connectionsmentioning

confidence: 96%

Organization of pontocerebellar projections to identified climbing fiber zones in the rat

Pijpers

Ruigrok

2006

J of Comparative Neurology

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“…The situation is much less clear with regard to the mossy fiber systems. Different cerebellar lobules or areas tend to receive mossy fibers from distinct sources (Brodal, 1981;Ito, 1984), and some relationship to the aldolase C compartments has been reported for mossy fiber projections from the basilar pontine nucleus , lateral reticular nucleus (Ruigrok and Cella, 1995;, external cuneate nucleus (ECuN), spinal cord (Matsushita et al, 1991;Ji and Hawkes, 1994;Akintunde and Eisenman, 1994), and trigeminal system (Hallem et al, 1999). However, these studies do not supply information on the actual density or arrangements of mossy fiber rosettes, since they were done with retrograde labeling, mass anterograde labeling, or receptive field mapping.…”

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confidence: 95%

Projection patterns of single mossy fiber axons originating from the dorsal column nuclei mapped on the aldolase C compartments in the rat cerebellar cortex

Quy

Fujita

Sakamoto

et al. 2011

J of Comparative Neurology

116

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Although cerebellar mossy fibers are the most abundant cerebellar afferents and are deeply involved in cerebellar function, the organization of their projection has remained obscure, particularly in relation to cerebellar compartmentalization. The dorsal column nuclei (DCN) are a major source of cerebellar mossy fibers and possess distinct somatotopic representations of specific somatosensory submodalities. We reconstructed individual dextran-labeled DCN axons completely from serial sections and mapped their terminals on the longitudinal cerebellar compartments that were visualized by aldolase C immunostaining to clarify their projection pattern. Individual axons branched and formed about 100 rosette terminals in the cerebellar cortex, but infrequently projected to the cerebellar nuclei (1 out of 15 axons). Cortical terminals were clustered in multiple areas in the vermis and pars intermedia mostly, but not exclusively, ipsilateral to the origin of the axon. The gracile, cuneate, and external cuneate nuclei (ECuN) mainly projected to the copula pyramidis and lobule V, paramedian and simple lobules, and lobules I-V and VIII-IX, respectively, although there was some overlap. The majority of terminals were located within aldolase C negative or lightly positive compartments. However, terminals of a single axon can be located on aldolase C-negative as well as on aldolase C-positive compartments. In particular, the rostral ECuN, which is responsive to shoulder movements, projected consistently to lobule IX, which were mostly aldolase C-positive. In sum, DCN-cerebellar axons project to multiple compartments with terminals clustered mainly in the conventional spinocerebellar region with a coarse topography, which shows some relationship to the cortical compartments defined by aldolase C.

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“…The granular layer is also subdivided into stripes (for review, see Ozol and Hawkes, 1997) that also align with the overlying Purkinje cell compartments [e.g., mossy fiber terminal fields (Matsushita et al, 1991;Akintunde and Eisenman, 1994;Ji and Hawkes, 1994;Voogd et al, 2003;Pijpers et al, 2006)], and an elaborate mosaic of patches is revealed both in tactile receptive field maps (Welker, 1987) and by histological treatments (Hawkes et al, , 1998. Finally, functional studies have also demonstrated parasagittal stripes in the cerebellum Larson, 1973, 1980) (for review, see Voogd et al, 1996) with direct correlations with particular Purkinje cell stripes (Chockkan and Hawkes, 1994;Chen et al, 1996;Hallem et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Golgi Cell Dendrites Are Restricted by Purkinje Cell Stripe Boundaries in the Adult Mouse Cerebellar Cortex

Sillitoe¹,

Chung²,

Fritschy³

et al. 2008

J. Neurosci.

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Despite the general uniformity in cellular composition of the adult cerebellar cortex, there is a complex underlying pattern of parasagittal stripes of Purkinje cells with characteristic molecular phenotypes and patterns of connectivity. It is not known whether interneuron processes are restricted at stripe boundaries. To begin to address the issue, three strategies were used to explore how cerebellar Golgi cell dendrites are organized with respect to parasagittal stripes: first, double immunofluorescence staining combining anti-neurogranin to identify Golgi cell dendrites with the Purkinje cell compartmentation antigens zebrin II/aldolase C, HNK-1, and phospholipase C␤4; second, zebrin II immunohistochemistry combined with a rapid Golgi-Cox impregnation procedure to reveal Golgi cell dendritic arbors; third, stripe antigen expression was used on sections of a GlyT2-EGFP transgenic mouse in which reporter expression is prominent in Golgi cell dendrites. In each case, the dendritic projections of Golgi cells were studied in the vicinity of Purkinje cell stripe boundaries. The data presented here show that the dendrites of a cerebellar interneuron, the Golgi cell, respect the fundamental cerebellar stripe cytoarchitecture.

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Spatial correspondence between tactile projection patterns and the distribution of the antigenic Purkinje cell markers anti-zebrin I and anti-zebrin II in the cerebellar folium crus IIa of the rat

Cited by 77 publications

References 38 publications

Organization of pontocerebellar projections to identified climbing fiber zones in the rat

Organization of pontocerebellar projections to identified climbing fiber zones in the rat

Projection patterns of single mossy fiber axons originating from the dorsal column nuclei mapped on the aldolase C compartments in the rat cerebellar cortex

Golgi Cell Dendrites Are Restricted by Purkinje Cell Stripe Boundaries in the Adult Mouse Cerebellar Cortex

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