Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis

Mulholland, Alannah; Vitorino, Rita; Hojjat, Seyed-Parsa; Ma, A.Y.; Zhang, L.; Lee, L.; Carroll, Timothy J.; Cantrell, C.G.; Figley, Chase R.; Aviv, Richard I.

doi:10.3174/ajnr.a5410

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…Previous research on brain perfusion in MS agrees that cerebral perfusion changes tend to be different depending on the MS phenotype independent from the perfusion technique, that is, ASL [3,16] or dynamic susceptibility contrast [13,14,17,34]. Rashid [3] found that there was hypoperfusion of the grey matter and adjacent white matter of MS patients compared to control subjects, greater in the PPMS and secondary progressive MS (SPMS) subgroups.…”

Section: Discussionmentioning

confidence: 99%

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

Testud

Delacour

Ahmadi

et al. 2022

Euro J of Neurology

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Background and purpose Extent and dynamic of neurodegeneration in progressive multiple sclerosis (MS) might be reflected by global and regional brain perfusion, an outcome at the intercept between structure and function. Here, we provide a first insight into the evolution of brain perfusion and its association with disability in primary progressive MS (PPMS) over several years. Methods Seventy‐seven persons with PPMS were followed over up to 5 years. Visits included a 3‐T magnetic resonance imaging with pulsed arterial spin labelling perfusion, the Timed 25‐Foot Walk, 9‐Hole Peg Test (NHPT), Symbol Digit Modalities Test (SDMT), and Expanded Disability Status Scale (EDSS). We extracted regional cerebral blood flow surrogates and compared them to 11 controls. Analyses focused on cortical and deep grey matter, the change over time, and associations with disability on the regional and global levels. Results Baseline brain perfusion of patients and controls was comparable for the cortex (p = 0.716) and deep grey matter (p = 0.095). EDSS disability increased mildly (p = 0.023), whereas brain perfusion decreased during follow‐up (p < 0.001) and with disease duration (p = 0.009). Lower global perfusion correlated with higher disability as indicated by EDSS, NHPT, and Timed 25‐Foot Walk (p < 0.001). The motor task NHPT showed associations with 20 grey matter regions. In contrast, better SDMT performance correlated with lower perfusion (p < 0.001) in seven predominantly frontal regions, indicating a functional maladaptation. Conclusions Decreasing perfusion indicates a putative association with MS disease mechanisms such as neurodegeneration, reduced metabolism, and loss of resilience. A low alteration rate limits its use in clinical practice, but regional association patterns might provide a snapshot of adaptive and maladaptive functional reorganization.

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Section: Discussionmentioning

confidence: 99%

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

Testud

Delacour

Ahmadi

et al. 2022

Euro J of Neurology

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“…Так, астроциты контактируют с внутримозговыми кровеносными сосудами, обладают влиянием на их диаметр и церебральный кровоток, а также участвуют в поддержании ионного баланса в перехватах Ранвье. Снижение аксональной активности, КЛИНИКА И ДИАГНОСТИКА приводящей к уменьшению выхода ионов К + , может представлять один из механизмов, приводящих к меньшему накоплению К + в астроцитах и, соответственно, меньшим высвобождением его в периваскулярное пространство, что нарушает процесс вазодилатации [30][31][32].…”

Section: Discussionunclassified

Brain atrophy and perfusion changes in patients with remitting and secondary progressive multiple sclerosis

Krotenkova

Bryukhov

Кротенкова

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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High density lipoprotein cholesterol and apolipoprotein A-I are associated with greater cerebral perfusion in multiple sclerosis

Jakimovski

Zivadinov

Dwyer

et al. 2020

Journal of the Neurological Sciences

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Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis

Cited by 7 publications

References 26 publications

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function

Brain atrophy and perfusion changes in patients with remitting and secondary progressive multiple sclerosis

High density lipoprotein cholesterol and apolipoprotein A-I are associated with greater cerebral perfusion in multiple sclerosis

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