Spatial control of sensory adaptation modulates mechanosensing inPseudomonas aeruginosa
Ramiro Patino,
Marco J. Kühn,
Henriette Macmillan
et al.
Abstract:SummarySensory signaling pathways use adaptation to dynamically respond to changes in their environment. Here, we report the mechanism of sensory adaptation in the Pil-Chp mechanosensory system, which the important human pathogenPseudomonas aeruginosauses to sense mechanical stimuli during surface exploration. Using biochemistry, genetics, and cell biology, we discovered that the enzymes responsible for adaptation, a methyltransferase and a methylesterase, are segregated to opposing cell poles asP. aeruginosae… Show more
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