Abstract:mTOR complex 1 (mTORC1) integrates inputs from multiple pathways, such as PI3K/Akt, AMPK, Ca2+, and cAMP/PKA, and senses diverse signals to regulate cell growth, protein translation, and proliferation. Although the subcellular compartmentalization of signaling pathways can enhance signal specificity and efficiency, the spatial regulation of mTORC1 and its specific functions are still poorly understood. A pool of mTORC1 associated with the outer mitochondrial membrane has previously been identified but the func… Show more
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