“…These studies have shown atypical asymmetries in mesial temporal and parietal regions in individuals at risk for AD (Reiman, Caselli, Yun, Chen, et al, 1996;Small et al, 1995;Soininen et al, 1994). Findings of lateralized cognitive profiles in at-risk individuals also are consistent with the asymmetric neuropsychological profiles identified in mildly demented patients with AD (Albert et al, 1990;Delis et al, 1992;Demadura et al, 2001). The lateralized cognitive deficits noted in these studies presumably reflect lateralized onset in AD with asymmetric changes likely to present in temporoparietal regions (Franceschi et al, 1995;Grady et al, 1990;Haxby et al, 1990).…”