Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex
Charlotte S. Herber,
Karishma J.B. Pratt,
Jeremy M. Shea
et al.
Abstract:SummaryAcross species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network-level spatial coding in aged MEC is unknown. Here, we leveragedin vivoelectrophysiology to assess MEC function in young, middle-aged, and aged mice navigating virtual environments. In aged grid cells, we observed impaired stabilization of context-specific spatial firing, correlated with spatial memory deficits. Additionally,… Show more
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