Spatial ciliary signaling regulates the dorsal/ventral regionalization of human brain organoids
Issei S. Shimada,
Akari Goto,
Yutaka Hashimoto
et al.
Abstract:Regionalization of the brain is a fundamental question in human developmental biology. Primary cilia are known for a critical organelle for dorsal/ventral fate of brain formation in mice, but little is known about how signaling in the primary cilia regulate regionalization of the human brain. Here, we found that signaling in the primary cilia function in regionalization of the brain using brain organoids derived from human induced pluripotent stem (iPS) cells. Deletion of a ciliary GTPase,ARL13B, induced parti… Show more
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