Spatial characteristics of the oscillatory potentials of the electroretinogram

Wachtmeister, Lillemor

doi:10.1111/j.1755-3768.1986.tb00686.x

Cited by 13 publications

(15 citation statements)

References 23 publications

(24 reference statements)

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“…An additional finding in this study was that patients (cases 230:1, 004:5 and 013:5) presenting low or nonmeasurable CS also had a low, reduced or nonrecordable oscillatory response. In spite of the comparatively small number of observations in this study this finding may support previous results on the OPs reflecting the activity of second-order neurons to which visual information converges from the whole retina [41]. In other words, it appears that the degenerative changes in the inner retina of BD are followed by severely affected CS at an early stage of BD.…”

Section: Discussionsupporting

confidence: 81%

Effects of prolonged dark adaptation in patients with retinitis pigmentosa of Bothnia type: an electrophysiological study

et al. 2007

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Bothnia dystrophy (BD) is a variant of recessive retinitis punctata albescens (RPA), caused by the missense mutation R233W in cellular retinaldehyde-binding protein (CRALBP), which is localized in the retinal pigment epithelium (RPE) and Müller cells of the retina. The purpose of this study was, by examining the electrophysiological responses of the retina, to evaluate the capacity of recovery of the whole retinal area and different cell types induced by extremely prolonged dark adaptation (DA) in BD disease and to gain further understanding of the pathogenesis of BD. Six young patients underwent bilateral full-field ERGs after 24 h of DA in one eye and standard DA in the fellow eye. The results were also compared with the effect of prolonged DA (10 h), previously studied in the same patients. After extremely prolonged DA (24 h) the rod b-wave and the mixed rod-cone a-wave responses reached normal though delayed amplitudes. An increase, up to normal level, in the oscillatory response was found. There was no obvious recovery of the cone response. We conclude that in young BD patients during extremely prolonged DA there is a significant additional capacity of recovery of rod function and also significant gain of activity in the inner retinal layer. A continuous but slow regeneration of rod photopigment seems to occur at least up to 24 h. The visual process in the RPE is retarded and CRALBP acts in this process; also, the Müller cells of the retina seem to be involved. The findings also support an extremely slow synthesis of photopigments and irreversibly disturbed cone function early in BD.

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Section: Discussionsupporting

confidence: 81%

Effects of prolonged dark adaptation in patients with retinitis pigmentosa of Bothnia type: an electrophysiological study

et al. 2007

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“…How the conscious visual experience emerges from neuronal spiking and field potential activities has been an intriguing but elusive problem of neuroscience (Wachtmeister ). Melloni et al.…”

Section: Introductionmentioning

confidence: 99%

“…How the conscious visual experience emerges from neuronal spiking and field potential activities has been an intriguing but elusive problem of neuroscience (Wachtmeister 1986). Melloni et al (2009) theorized that organized local field potential oscillations along the hierarchy of the visual system play a critical role in conscious visual perception.…”

Section: Introductionmentioning

confidence: 99%

Retino-cortical stimulus frequency-dependent gamma coupling: evidence and functional implications of oscillatory potentials

et al. 2016

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Long‐range gamma band EEG oscillations mediate information transmission between distant brain regions. Gamma band‐based coupling may not be restricted to cortex‐to‐cortex communication but may include extracortical parts of the visual system. The retinogram and visual event‐related evoked potentials exhibit time‐locked, forward propagating oscillations that are candidates of gamma oscillatory coupling between the retina and the visual cortex. In this study, we tested if this gamma coupling is present as indicated by the coherence of gamma‐range (70–200 Hz) oscillatory potentials (OPs) recorded simultaneously from the retina and the primary visual cortex in freely moving, adult rats. We found significant retino‐cortical OP coherence in a wide range of stimulus duration (0.01–1000 msec), stimulus intensity (800–5000 mcd/mm2), interstimulus interval (10–400 msec), and stimulus frequency (0.25–25 Hz). However, at low stimulus frequencies, the OPs were time‐locked, flickering light at 25 Hz entrained continuous OP coherence (steady‐state response, SSR). Our results suggest that the retina and the visual cortex exhibit oscillatory coupling at high‐gamma frequency with precise time locking and synchronization of information transfer from the retina to the visual cortex, similar to cortico‐cortical gamma coupling. The temporal fusion of retino‐cortical gamma coherence at stimulus rates of theater movies may explain the mechanism of the visual illusion of continuity. How visual perception depends on early transformations of ascending sensory information is incompletely understood. By simultaneous measurement of flash‐evoked potentials in the retina and the visual cortex in awake, freely moving rats, we demonstrate for the first time that time‐locked gamma oscillatory potentials exhibit stable retino‐cortical synchrony across a wide range of stimulus parameters and that the temporal continuity of coherence changes with stimulus frequency according to the expected change in the visual illusion of continuity.

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“…Most features of the preparation and recording are treated in detail elsewhere (Wachtmeister 1986;Wachtmeister & Hahn 1987). The frog (Rana pipiens and temporaria) eye cup preparation was used (Wachtmeister & Hahn 1987).…”

Section: Methodsmentioning

confidence: 99%

“…The proximal negative response (PNR) of the retina is an extracellular field potential of negative polarity representing primarily amacrine cell ac-tivity (Burkhardt 1970;Proenza & Burkhardt 1973;Ogden 1973). Its fundamental properties have been studied in several species (Gouras 1958;Ogden & Wylie 1971;Holden 1972;Burkhardt 1970;Proenza & Brukhardt 1973;Ogden 1973;Dowling & Ripps 1977), and the PNR has clearly been isolated from the a-and b-waves as well as from the oscillatory potentials (OPs) of the electroretinogram (ERG) (Wachtmeisster & Dowling 1978;Wachtmeister 1986). The PNR truely reflects the contrast function and the adaptive state of the inner retina (Burkhardt 1970;Dowling & Ripps 1977).…”

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confidence: 99%

Spatial summation and visual adaptation in the inner part of the frog retina

Hahn

Wachtmeister

1989

Acta Ophthalmologica

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The spatial summation of the proximal negative response (PNR) of frog retina was analyzed during different states of adaptation induced by repetitive light stimulation with either 15 sec or 1 min interstimulus interval. The spatial summation area of the PNR was found to be wider during relatively more dark adapted conditions compared to relatively more light adapted ones. This finding indicates that lateral mechanisms in the inner network of the retina seem to be activated by adapting stimuli. Secondly, the results suggest that the activity of the amacrines, as reflected by the PNR, may initiate the series of neuronal events which underlie the oscillatory potentials (OPs) of the electroretinogram (ERG).

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Spatial characteristics of the oscillatory potentials of the electroretinogram

Cited by 13 publications

References 23 publications

Effects of prolonged dark adaptation in patients with retinitis pigmentosa of Bothnia type: an electrophysiological study

Effects of prolonged dark adaptation in patients with retinitis pigmentosa of Bothnia type: an electrophysiological study

Retino-cortical stimulus frequency-dependent gamma coupling: evidence and functional implications of oscillatory potentials

Spatial summation and visual adaptation in the inner part of the frog retina

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