Spatial aspects of pain modulation are not disrupted in adolescents with migraine

Nahman‐Averbuch, Hadas; Thomas, Priya L.; Schneider, Victor J.; Chamberlin, Leigh A.; Peugh, James; Hershey, Andrew D.; Powers, Scott W.; Coghill, Robert C.; Cd, King

doi:10.1111/head.14017

Cited by 9 publications

(11 citation statements)

References 54 publications

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“…This manuscript includes data from eight different studies including unpublished studies, involving psychological and experimental pain outcome parameters [7,8,54,57]. For psychological measures, we focused on anxiety, depression and pain catastrophizing.…”

Section: Methodsmentioning

confidence: 99%

Relationships between Psychological Factors and Experimental Pain Outcomes in Healthy Individuals: Results from 8 Studies

Nahman‐Averbuch¹,

Ia²,

Bm³

et al. 2021

Preprint

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Psychological factors, such as anxiety, depression, and pain catastrophizing, may affect how healthy individuals experience experimental pain. However, current literature puts forth contradictory results, possibly due to differing study methodologies, such as the type of psychophysical measure or survey. To better understand such results, this paper analyzed the relationships between psychological factors and experimental pain outcomes across eight different studies (total n= 595) conducted in different populations of healthy adult and adolescent participants. Analyses were conducted with and without controlling for sex, age, and race. Each study was analyzed separately and as part of an aggregate analysis. Even without correction for multiple comparisons, only a few significant relationships were found for the individual studies. Controlling for demographic factors had minimal effect on the results. Importantly, even the few statistically significant models showed relatively small effect sizes; psychological factors explained no more than 20% of the variability in experimental pain sensitivity of healthy individuals. The aggregate analyses revealed relationships between anxiety and PPT / cold pain ratings and between pain catastrophizing and PPT. Sample size calculations based on the aggregate analyses indicated that several hundred participants would be required to correctly detect relationships between these psychological factors and pain measures. These overall negative findings suggest that anxiety, depression, and pain catastrophizing in healthy individuals may not be meaningfully related to experimental pain outcomes. Furthermore, positive findings in the literature may be subject to small group effects and publication bias towards positive findings.

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Section: Methodsmentioning

confidence: 99%

Relationships between Psychological Factors and Experimental Pain Outcomes in Healthy Individuals: Results from 8 Studies

Nahman‐Averbuch¹,

Ia²,

Bm³

et al. 2021

Preprint

Self Cite

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“…This study is not related to previously published studies from our group. [26][27][28] There are no other publications related to this dataset (from healthy adolescents or patients).…”

Section: Materials S and Me Thodsmentioning

confidence: 99%

New insight into the neural mechanisms of migraine in adolescents: Relationships with sleep

et al. 2022

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Objective: This case-control study examines if measures of subjective and objective (actigraphic) sleep difficulties mediate alterations in amygdalar connectivity in adolescents with migraine compared to healthy adolescents. Background: Adolescents with migraine have different functional connectivity of the amygdala compared to individuals without migraine. Sleep is often disturbed in adolescents with migraine, and could contribute to the alterations in functional connectivity. Methods: Twenty adolescents with migraine and 20 healthy controls were recruited from Cincinnati Children's Hospital. Participants completed surveys about their headaches and overall sleep quality, sleep hygiene, and perceived sleep difficulties (Insomnia Severity Scale [ISI]); completed wrist-worn actigraphy; and underwent a magnetic resonance imaging scan.Results: Adolescents with migraine differed from healthy controls only in perceived difficulty in sleep initiation and maintenance (ISI: 8.5 ± 4.7 and 4.5 ± 3.7[mean ± standard deviation], −4.00 [95% confidence: −6.7 to −1.3], p = 0.005) and had greater functional connectivity between the amygdala and the posterior cingulate cortex, precuneus, dorsolateral prefrontal, sensorimotor, and the occipital cortexes.

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“…Interestingly, the CPM effect duration after termination of the conditioning stimulus seems to be relatively short, varying from 0 to 10 min ( Imai et al, 2016 ; Lewis et al, 2012 ; Vaegter, Handberg & Graven-Nielsen, 2016 ). Local, regional and remote locations are often selected in clinical studies to differentiate between primary, secondary, or widespread hyperalgesia or gain of nerve fibre function ( Courtney et al, 2016 ; Nahman-Averbuch et al, 2020 ; Ng et al, 2014 ; Owens et al, 2016 ; Vaegter, Handberg & Graven-Nielsen, 2014 ). Therefore, the application of test stimuli on multiple locations takes time, which may justify using a parallel design where the duration of the conditioning stimulus can be extended until the last test stimulus ( Pud, Granovsky & Yarnitsky, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

No relevant differences in conditioned pain modulation effects between parallel and sequential test design. A cross-sectional observational study

Reezigt

Kielstra

Coppieters

et al. 2021

PeerJ

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Background Conditioned pain modulation (CPM) is measured by comparing pain induced by a test stimulus with pain induced by the same test stimulus, either during (parallel design) or after (sequential design) the conditioning stimulus. Whether design, conditioning stimulus intensity and test stimulus selection affect CPM remains unclear. Methods CPM effects were evaluated in healthy participants (N = 89) at the neck, forearm and lower leg using the cold pressor test as the conditioning stimulus. In three separate experiments, we compared the impact of (1) design (sequential versus parallel), (2) conditioning stimulus intensity (VAS 40/100 versus VAS 60/100), and (3) test stimulus selection (single versus dual, i.e., mechanical and thermal). Statistical analyses of the main effect of design (adjusted for order) and experiment were conducted using linear mixed models with random intercepts. Results No significant differences were identified in absolute CPM data. In relative CPM data, a sequential design resulted in a slightly lower CPM effect compared to a parallel design, and only with a mechanical test stimulus at the neck (−6.1%; 95% CI [−10.1 to −2.1]) and lower leg (−5.9%; 95% CI [−11.7 to −0.1]) but not forearm (−4.5%; 95% CI [−9.0 to 0.1]). Conditioning stimulus intensity and test stimulus selection did not influence the CPM effect nor the difference in CPM effects derived from parallel versus sequential designs. Conclusions Differences in CPM effects between protocols were minimal or absent. A parallel design may lead to a minimally higher relative CPM effect when using a mechanical test stimulus. The conditioning stimulus intensities assessed in this study and performing two test stimuli did not substantially influence the differences between designs nor the magnitude of the CPM effect.

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Spatial aspects of pain modulation are not disrupted in adolescents with migraine

Cited by 9 publications

References 54 publications

Relationships between Psychological Factors and Experimental Pain Outcomes in Healthy Individuals: Results from 8 Studies

Relationships between Psychological Factors and Experimental Pain Outcomes in Healthy Individuals: Results from 8 Studies

New insight into the neural mechanisms of migraine in adolescents: Relationships with sleep

No relevant differences in conditioned pain modulation effects between parallel and sequential test design. A cross-sectional observational study

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