Spatial and Temporal Relationship between Structural Progression and Disc Hemorrhage in Glaucoma in a 3-Year Prospective Study

Higashide, Tomomi; Ohkubo, Shinji; Udagawa, Sachiko; Sugiyama, Kazuhisa; Tanihara, Hidenobu; Araie, Makoto; Tomita, Goji; Matsumoto, Chota; Fukuchi, Takeo; Tomidokoro, Atsuo; Hangai, Masanori; Kawata, Hisashi; Inai, Maya; Tanaka, Yuki

doi:10.1016/j.ogla.2020.08.008

Cited by 3 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The no-DH group might have included patients with undetected DHs, considering the short duration of DH [ 39 ]. However, the interval of three months for DH observation in this study is comparable to that adopted in other studies on DHs [ 11 , 14 , 15 , 16 , 17 , 18 , 20 , 22 , 24 , 29 , 32 , 33 , 34 , 36 , 37 , 38 ]. Although we did not examine the association between DH and systemic diseases or drug usage, systemic hypertension [ 19 , 21 ], diabetes [ 19 , 45 ] and use of aspirin [ 45 ] were reported to be significantly associated with DH occurrence.…”

Section: Discussionsupporting

confidence: 81%

“…Instead, the number of visits with DH should not be seriously affected by the underestimation of the true DH occurrence if the follow-up visits are regular and uniform for all study participants. Using this variable, Higashide et al reported that more visits with DH at the progressive disc location were significantly associated with a shorter time to progression from baseline in a 3-year prospective study with 3-monthly follow-up visits [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have demonstrated that inferior VF loss, compared with superior RNFL defects, is more frequently observed in glaucoma patients with diabetes or ischemic changes in the brain, suggesting that the superior hemiretina is more susceptible to ischemic changes [ 40 , 41 ]. Higashide et al reported that structural progression independent of DH was more common in the superior hemiretina than in the inferior hemiretina [ 29 ]. Thus, the more frequent structural progression in the absence of DH may have resulted in a weaker association between DH and GCC thinning in the superior hemiretina.…”

Section: Discussionmentioning

confidence: 99%

“…Jansonius et al reported that more clock hours of the superior half of the optic disc than of the inferior half were devoted to the fovea in a mathematical model describing retinal nerve fiber bundle trajectories [ 42 ]. Accordingly, the superior arcuate nerve fibers entering the 11 o’clock disc location, the second most frequent site of DHs, ran more peripherally than the inferior fibers belonging to the vertically line-symmetric disc location (i.e., 7 o’clock, the most common site of DH occurrence) [ 29 , 42 ]. Given the superior outer sector locates outside of the “Cirrus” GCIPL analytical area, the difference in superior macular structural changes between no-DH and DH groups might not have been detected using GCIPL thickness slope instead of GCC thickness slope.…”

Section: Discussionmentioning

confidence: 99%

“…Higashide et al reported that photographic structural progression, which was mostly detected as widening of RNFL defects, occurred comparably in both the superior and inferior hemiretinas in a 3-year prospective study [ 29 ]. Nonetheless, the progression sites in the superior hemiretina were less frequently associated with DH than those in the inferior hemiretina.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Tachibana

Higashide

Nitta

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

Disc hemorrhage (DH) is often associated with glaucoma progression. A vertically asymmetrical pattern is typical of glaucoma progression, but it remains unclear whether the association between DH and glaucoma progression differs between the superior and inferior hemiretinas. We compared the thickness changes of the macular ganglion cell complex (GCC) in the hemiretinas of normal-tension glaucoma patients with or without DH, as well as between hemiretinas positive and negative for DH, during five years. Both the superior and inferior hemiretinas in the DH-positive group had a more negative GCC thickness slope in association with more DH counts compared to those in the DH-negative group. Conversely, only the inferior hemiretina exhibited a significant relationship between GCC thickness slope and DH counts when hemiretinas positive and negative for DH in the DH-positive group were compared. In the superior hemifield, the slope of the total deviation changes in the DH-positive hemifield of the DH-positive group was more negative compared to that of the DH-negative group. The association between DH and glaucoma progression in the macular GCC may be stronger in the inferior hemiretina, suggesting that more attention should be paid to DH in the inferior disc area as a sign of glaucoma progression.

show abstract

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Tachibana

Higashide

Nitta

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

Prediction of glaucoma progression by 24-h contact lens sensor profile in patients with normal-tension glaucoma

Higashide,

Udagawa,

Nakazawa

et al. 2024

Sci Rep

View full text Add to dashboard Cite

An effective model of clinical examination and monitoring of glaucoma patients

Дорофеев¹,

Baryshnikova

Kirilik³

et al. 2022

Glaucoma

View full text Add to dashboard Cite

Open-angle glaucoma is a chronic progressive optic neuropathy characterized by morphological changes in the optic nerve head and retinal nerve fibers layer in the absence of other eye diseases.Regular medical check-ups are necessary to assess the progression of glaucoma, to correct the treatment regimen or prescribe surgical interventions, to control the stabilization of the glaucoma process and to preserve visual functions for longer period. When planning the number of monitoring visits, it is necessary to carefully study the prognostic risk factors, since they are statistically associated with the development and progression of glaucoma. Closer observation of patients with glaucoma reduces the risk of irreversible changes in the organ of vision.Patient compliance is of particular importance in the progression of glaucoma. The adherence rate in the treatment of glaucoma is relatively lower compared to other chronic diseases that require lifelong treatment.Currently, there is no effective model of regular checkups for glaucoma patients, therefore this direction requires improvement and development, both in the standards and timing of patient examination, and in the use of remote methods of glaucoma control. The disadvantage of the current medical check-ups routine is the lack of individual approach to patients, lack of equipment in the offices of regional ophthalmologists, and lack of specialized glaucoma offices.The tense epidemiological situation during the Covid-19 pandemic, gave understanding that while in-person consultations and remote consultations (telemedicine) cannot replace each other, a combination of these methods is cost-effective, can reduce the uneven distribution of ophthalmic resources, reduce the burden on the doctor and the rate of misdiagnosis. The situation was aggravated by the closure of ophthalmological hospitals and an increase in the waiting time for consultation in higher specialized medical institutions, which probably entails an increase in patients with progression of the glaucomatous process and the economic burden on both the state and the patients themselves.Telemedicine should be gradually introduced into everyday practice, for which it is advisable to create a single database of glaucoma patients to track the glaucomatous process.

show abstract

Spatial and Temporal Relationship between Structural Progression and Disc Hemorrhage in Glaucoma in a 3-Year Prospective Study

Cited by 3 publications

References 33 publications

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Prediction of glaucoma progression by 24-h contact lens sensor profile in patients with normal-tension glaucoma

An effective model of clinical examination and monitoring of glaucoma patients

Contact Info

Product

Resources

About