Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy

Luzzago, C.; Ebranati, Erika; Sassera, Davide; Presti, Alessandra Lo; Lauzi, Stefania; Gabanelli, Elena; Ciccozzi, Massimo; Zehender, Gianguglielmo

doi:10.1016/j.meegid.2011.12.007

Cited by 27 publications

(24 citation statements)

References 36 publications

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“…This is consistent with the studies published in several European countries, including Germany, France, Italy and Portugal, in which the most prevalent BVDV groups were reported to be 1b, 1d and 1e (Tajima et al, 2001;Barros et al, 2006;Jackova et al, 2008;Luzzago et al, 2012). On the contrary, in the UK, BVDV-1a seems to be the most frequent (Booth et al, 2013); this group has also been detected in Spain.…”

Section: Discussionsupporting

confidence: 91%

“…This species appeared more sporadically in Europe with a first identification in Belgium in 1991 (Letellier et al, 2010). Afterwards it has been isolated in France on several occasions (Vilcek et al, 2001;Jackova et al, 2008) as well as in Italy (Luzzago et al, 2012) or the UK (Wakeley et al, 2004), in none of these cases correlated with severe clinical disease. However, in Portugal, the BVDV2a and 2b groups have been found in farms showing clinical signs of hemorrhagic disease (Barros et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…While BVDV-2 is widespread in the USA and Canada (Pellerin et al, 1994;Fulton et al, 2005;Ridpath et al, 2011), it has been detected more sporadically in Europe, although, is increasingly being identified over the last years (Wakeley et al, 2004;Barros et al, 2006;Jackova et al, 2008;Letellier et al, 2010;Luzzago et al, 2012;Aduriz et al, 2015;Gethmann et al, 2015;Diéguez et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review

2017

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Bovine viral diarrhea virus (BVDV), a member of the genus Pestivirus of the family Flaviviridae, causes significant losses in cattle farming worldwide because of reduced milk production, increased mortality of young animals and reproductive, respiratory and intestinal problems. The virus is characterized by an important genetic, and consequently antigenic and pathogenic diversity. Knowing the variability of viral strains present in a population provides valuable information, particularly relevant for control programs development, vaccination recommendations and even identification of likely infection sources. Such information is therefore important at both local and regional levels. This review focuses on the genetic diversity of BVDV isolates infecting cattle in Spain over the last years. According to the published data, the most prevalent BVDV group in Spain was 1b, and to a lesser extent 1d, 1e and 1f. Besides, BVDV-2 has also been found in Spain with several ratified isolates. The studies carried out in Spain also showed increased genetic heterogeneity of BVDV strains, possibly due to a more intensive use of analytical tools available, presenting studies with increasingly greater sample sizes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review

2017

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“…Both phylogeographic analyses on the whole dataset and on the selection of Npro dataset pointed out that subtype 1f entered Aosta Valley from Piedmont. On the whole BVDV-1f showed a gravity-like dynamic of the infection, originating in larger animal populations then diffusing to smaller populations following patterns of animal movements, as already described for other BVDV subtypes in Italy (Luzzago et al, 2012). Due to the lack of a systematic typing of BVDV in the 1960s, the origin of the viral dispersion from Veneto may be only hypothesized.…”

Section: Discussionmentioning

confidence: 67%

Phylogeography, phylodynamics and transmission chains of bovine viral diarrhea virus subtype 1f in Northern Italy

Cerutti

Luzzago

Lauzi

et al. 2016

Infection, Genetics and Evolution

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“…The North macroarea showed the highest genetic variability, with nine out of 11 BVDV-1 subtypes and the cocirculation of BVDV-2, confirming the predominant role of this area in BVDV introduction into Italy from other European countries [21]. Nevertheless, the identification of some sporadic genetic variants restricted to the Center (BVDV-1l) or the South (BVDV-1c and HoBi-like) and the presence of eight BVDV genotypes and subtypes in the South, despite the low frequency of total sequences, suggest that BVDV has been likely introduced in Italy also through different commercial livestock flows or the use of contaminated biological products.…”

Section: Discussionmentioning

confidence: 93%

Extended Genetic Diversity of Bovine Viral Diarrhea Virus and Frequency of Genotypes and Subtypes in Cattle in Italy between 1995 and 2013

Luzzago

Lauzi

Ebranati

et al. 2014

BioMed Research International

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Genetic typing of bovine viral diarrhea virus (BVDV) has distinguished BVDV-1 and BVDV-2 species and an emerging putative third species (HoBi-like virus), recently detected in southern Italy, signaling the occurrence of natural infection in Europe. Recognizing the need to update the data on BVDV genetic variability in Italy for mounting local and European alerts, a wide collection of 5′ UTR sequences (n = 371) was selected to identify the frequency of genotypes and subtypes at the herd level. BVDV-1 had the highest frequency, followed by sporadic BVDV-2. No novel HoBi-like viruses were identified. Four distribution patterns of BVDV-1 subtypes were observed: highly prevalent subtypes with a wide temporal-spatial distribution (1b and 1e), low prevalent subtypes with a widespread geographic distribution (1a, 1d, 1g, 1h, and 1k) or a restricted geographic distribution (1f), and sporadic subtypes detected only in single herds (1c, 1j, and 1l). BVDV-1c, k, and l are reported for the first time in Italy. A unique genetic variant was detected in the majority of herds, but cocirculation of genetic variants was also observed. Northern Italy ranked first for BVDV introduction, prevalence, and dispersion. Nevertheless, the presence of sporadic variants in other restricted areas suggests the risk of different routes of BVDV introduction.

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Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy

Cited by 27 publications

References 36 publications

Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review

Bovine viral diarrhea virus (BVDV) genetic diversity in Spain: A review

Phylogeography, phylodynamics and transmission chains of bovine viral diarrhea virus subtype 1f in Northern Italy

Extended Genetic Diversity of Bovine Viral Diarrhea Virus and Frequency of Genotypes and Subtypes in Cattle in Italy between 1995 and 2013

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